MUNIX Variability in Healthy Subjects

Calculation of Normal MUNIX Variation in an Healthy Population

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03593265

Acronym

MUNIX

Enrollment

120

Registered

2018-07-20

Start date

2018-09-30

Completion date

2020-01-31

Last updated

2018-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

Motor unit number index (MUNIX) is an electrophysiological technique that estimates the number of motor units in a muscle. This data can be changed by natural evolution or by treatment in peripheral neuropathy. Alfortunately, normal value for MUNIX variation does not exist. Thus, it is difficult to assume improvement or worsening of the MUNIX for an individual subject. Our objective is to calculate normal variation of MUNIX in 4 muscles : tibialis anterior, abductor digiti mini, abductor pollicis brevis et deltoideus. Measurement will be performed at inclusion and 3 monthes later in 100 healthy subjects. This trial will be prospective in several French centres sepecialized in neuromuscular evaluation

Detailed description

Motor unit number index (MUNIX) is an electrophysiological technique that estimates the number of motor units in a muscle. This data can be changed by natural evolution or by treatment in peripheral neuropathy. Alfortunately, normal value for MUNIX variation does not exist. Thus, it is difficult to assume improvement or worsening of the MUNIX for an individual subject. Our objective is to calculate normal variation of MUNIX in 4 muscles: tibialis anterior, abductor digiti mini, abductor pollicis brevis et deltoideus. Measurement will be performed at inclusion and 3 monthes later in 100 healthy subjects. This trial will be prospective in several French centres sepecialized in neuromuscular evaluation

Interventions

OTHERMUNIX

Motor unit number index in 4 muscles: tibialis anterior, abductor digiti mini, abductor pollicis brevis et deltoideus

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Healthy subjects without neuromuscular disoreders or others diseases which can interfer with MUNIX measurement * More than 18 years old

Exclusion criteria

* Less than 18 years old * Diseases which can interfer with MUNIX measurement

Design outcomes

Primary

Measure	Time frame	Description
MUNIX	3 months	motor unit number inedx in 4 muscles: tibialis anterior, abductor digiti mini, abductor pollicis brevis et deltoideus

Secondary

Measure	Time frame	Description
MUSIX	3 months	muscle size index
CMAP amplitudes	3 months	the greatest possible amplitude

Countries

France

Contacts

Primary ContactEMILIEN DELMONT, MD

emilien.delmont@ap-hm.fr+33 4 91 38 49 46

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026