Bladder Cancer, Bladder Disease, Bladder Neoplasm, Micro-RNA
Conditions
Brief summary
We try to assess the potential role of telomerase reverse transcriptase and MicroRNA (miR-155) in diagnosis of non-muscle-invasive bladder cancer and their correlation with stage and grade of the tumor.
Interventions
DIAGNOSTIC_TESTMicroRNAs-155
Quantitative analysis of cell-free miR-155 using RT-qPCR.
DIAGNOSTIC_TESTHuman telomerase reverse transcriptase
Analysis TERT by TERT messenger RNA (mRNA)expression by reverse transcription-quantitative polymerase chain reaction.
Sponsors
Mansoura University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Men and women 18 years or older. * Patient with hematuria suspected to be of bladder origin clinically. * Willing to be participate in the study.
Exclusion criteria
* Patient having another malignancy. * Hematuria of other causes as trauma and stones
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sensitivity, specificity and positive and negative predictive values of combined MicroRNA-155 And Telomerase Reverse Transcriptase In diagnosis Of Non-Muscle Invasive Bladder Cancer | 1 year | compared by standard final pathological specimen |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| correlation between serum Vit D and Non-Muscle Invasive Bladder Cancer | 1 year | measured serum Vit D in ng/mL. |
Countries
Egypt
Outcome results
None listed