Using Three Different Final Irrigants and Showing Their Effects on the Success of Revascularization

Assessment of Implementing Nano-technology in the Irrigation Protocol of One Step Revascularization For Necrotic Mature Teeth

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03591172

Enrollment

Registered

2018-07-19

Start date

2018-09-30

Completion date

2019-09-30

Last updated

2018-07-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-operative Pain

Brief summary

this study will assess different irrigating materials on the success revascularization of necrotic mature teeth associated with PRF.

Detailed description

Nano-propolis and Propolis will be used as final endodontic irrigants and will be compared to saline in Revascularization of necrotic mature teeth.

Interventions

DRUGPropolis

Using propolis as a final irrigation in revascularization

DRUGNano-propolis

Using Nano-propolis as a final irrigation in revasculariztion

DRUGsaline

Using saline as a final irrigation in revasculariztion

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

15 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* mature teeth. * teeth with periapical periodontitis. * Maxillary anterior teeth * Patients should be free from any systemic disease * Patients who will agree to the consent and will commit to follow-up period.

Exclusion criteria

* Patients with immature roots. * Patients with any systemic disease that may affect normal healing. * Patients with swelling. .Pregnant females. .Patients who could/would not participate in a 1-year follow-up. .Patients with fistula. .Patients with old age. .Teeth with periodontal involvement. .Teeth with vertical root fractures. .Non-restorable teeth.

Design outcomes

Primary

Measure	Time frame	Description
post-operative pain: Visual analogue scale	1 year	post-operative pain evaluated using Visual analogue scale , 0 no pain, 10 severe pain.

Secondary

Measure	Time frame	Description
periapical healing	1 year	evaluated radiographically
sensitivity	1 year	electric pulp tester
survival	1 year	clinical evaluation

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026