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Efficacy of Licorice on Reducing Salivary Streptococcus Mutans Versus Chlorohexidine in Caries Risk Patients

Evaluation the Efficacy of a Herbal Licorice on Reducing Salivary Streptococcus Mutans Levels (A Randomized Clinical Trial)

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03590977
Enrollment
52
Registered
2018-07-18
Start date
2018-09-01
Completion date
2019-10-01
Last updated
2018-07-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caries, Dental

Keywords

Streptococcus Mutans, licorice, chlorohexidine, caries index

Brief summary

To compare the effect of a natural herbal licorice containing preventive measure alternative to chlorohexidine preventive measure to decrease the effect of streptococcus mutans.

Detailed description

A total number of fifty-two patients will be enrolled in the study. They will be divided into two groups: study group and control group. Study group will be subjected to licorice mouthwash and the control will be subjected to chlorohexidine mouth wash. Salivary bacterial count will be evaluated for both groups.

Interventions

OTHERlicorice extract mouthwash

mouth rinse that contains a natural herbal licorice root extract used as a preventive measure that reduce caries index.

mouth wash that contains chlorohexidine as an active component

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes

Inclusion criteria

* over 18 years old * co-operative patients * not allergic to licorice * not allergic to chlorohexidine

Exclusion criteria

* pregnancy * allergic patients to licorice * allergic patients to chlorohexidine * lack of compliance * evidence of parafunctional habits * patients with periodontal disease * xerostomia * participants that receive any microbial agent two weeks prior to the study

Design outcomes

Primary

MeasureTime frameDescription
salivary bacterial countafter one weekstreotococcus mutans bacterial count

Contacts

Primary Contactnancy helmy, Msc
nancy.helmy@dentistry.cu.edu.eg01002715841
Backup Contactsherine hafez, Phd
sherine.hafez@dentistry.cu.edu.eg01099296591

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026