Acute Kidney Injury
Conditions
Brief summary
This is a single center randomized trial that seeks to determine if the use of an automated real-time electronic medical record Acute Kidney Injury (AKI) risk score can improve patient outcomes through the use of an early standardized nephrology focused intervention.
Interventions
OTHEREarly Nephrology Consult (ENC)
The electronic risk prediction algorithm (ESTOP-AKI) will interface with electronic medical data to determine the likelihood for the patient to develop AKI. Early Nephrology Consult (ENC) will be implemented. A nephrologist will assess the subject and consult with their care team to advise a treatment plan during the hospitalization.
OTHERStandard of Care (SOC)
Subjects will receive nephrology consultation at the typical timepoint after symptoms of AKI appear.
Sponsors
University of Chicago
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age \>18 years old 2. Initial ESTOP AKI score ≥0.01 within the last 8 hours.
Exclusion criteria
1. Voluntary refusal or missing written consent of the patient / legal representative. 2. Patients with a known history of end-stage renal disease on dialysis (including renal transplantation). 3. Patients without a measured serum creatinine value during their inpatient stay. 4. Patients with a creatinine \>4.0 mg/dl at the time of admission or available in the electronic health record (EHR) from the last 6 months. 5. Patients with prior episode of Kidney Disease Improving Global Outcomes (KDIGO) defined AKI during this same hospitalization- regardless of ESTOP AKI score. 6. Patients with prior renal consultation during their admission.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peak change in milligrams per deciliter (mg/dL) in serum creatinine (SCr) level over a 7-day interval | 7-day interval | The primary endpoint of interest, change in serum creatinine (SCr), is the peak change from study entry in SCr level over a 7-day interval. The change in SCr is defined as the maximal change in creatinine over this interval, and aim to detect a clinical difference in change in SCr between the SOC and ENC treatment groups. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORJay Koyner, MD
University of Chicago Medicine
Outcome results
None listed