Hepatic Blood Flow Changes During Fluid Challenge Assessed by MRI in Volunteers Subjects.

Hepatic Blood Flow Changes During Fluid Challenge Assessed by MRI in Volunteers Subjects: a Prospective Monocentric Study. PORTEAU Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03589261

Acronym

PORTEAU

Enrollment

Registered

2018-07-17

Start date

2018-09-06

Completion date

2019-03-29

Last updated

2025-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatic Flow Changes

Brief summary

Hepatic artery and portal flows are both regulated to assume the whole hepatic blood flow. Each counts for respectively 25% and 75%. That so-called buffer response assumes that when portal flow increases, hepatic artery flow decreases. During fluid challenge in intensive care unit, fluid challenge is often administered to improve hepatic perfusion. That observation is not demonstrated. The aim of the study is to test buffer response and portal flow during fluid challenge.

Detailed description

Prospective monocentric study at Amiens Hospital University. 20 volunteers subjects will be include after providing informed consent. Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI.

Interventions

DEVICEMRI (magnetic resonance imaging)

Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Fasting for the last 12 hours.

Exclusion criteria

* Claustrophobia * Any previous medical history disease; * Any abdominal surgical disease * Pregnancy or breastfeeding

Design outcomes

Primary

Measure	Time frame	Description
Portal blood flow measure before and after fluid challenge	Two hours: the difference in hepatic portal flow before and after a volume expansion of 500 ml NaCl 0.9%.	Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI (magnetic resonance imaging).

Secondary

Measure	Time frame	Description
Hepatic artery blood flow measure before and after fluid challenge	Two hours	Hepatic artery blood flow measure before and after a volume expansion of 500 ml NaCl 0.9%.

Other

Measure	Time frame	Description
Flow ratio of portal flow on hepatic artery flow	Two hours	Flow ratio of portal flow on hepatic artery flow before and after a volume expansion of 500 ml NaCl 0.9%.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026