Comparison of Effect of Equi-MAC Anesthetics on PSI

Comparison of the Effect of Sevoflurane and Desflurane on Patient State Index: A Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03587779

Enrollment

Registered

2018-07-16

Start date

2018-07-24

Completion date

2019-01-22

Last updated

2020-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Keywords

patient state index, sevoflurane, desflurane, minimum alveolar concentration

Brief summary

The aim of this study is to compare the patient state index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent volatile anesthesia.

Detailed description

There have been several studies comparing electroencephalogram-derived indices produced by sevoflurane and desflurane. However, to the best of our knowledge, there has been no study which compared the two inhaled anesthetics using patient state index. Therefore, the aim of this study is to compare the patient state index values produced by sevoflurane and desflurane at equi-MAC in patients undergoing single-agent inhalation anesthesia.

Interventions

DRUGSevoflurane

Throughout the study period, anesthesia is maintained with sevoflurane of age-corrected equivalent minimum alveolar concentration.

DRUGDesflurane

Throughout the study period, anesthesia is maintained with desflurane of age-corrected equivalent minimum alveolar concentration.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

19 Years to 65 Years

Healthy volunteers

Inclusion criteria

* patients aged between 19 and 65 yr * patients with American Society of Anesthesiologists physical status classification I or II * patients scheduled for elective surgery under volatile anesthesia * patients obtaining written informed consent

Exclusion criteria

* patients with a history of any psychiatric or neurological disease * patients receiving any medication affecting the autonomic or central nervous system * patients with a history of alcohol or drug abuse * pregnant or lactating women

Design outcomes

Primary

Measure	Time frame	Description
patient state index	After a 30-min waiting period from the induction of anesthesia	patient state index value at a steady-state anesthesia of equi-MAC

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026