Periodic Limb Movement and Genetic Generalized Epilepsy

The Relationship Between Periodic Limb Movement and Seizure Recurrence in Genetic Generalized Epilepsy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03587506

Acronym

Epilepsy

Enrollment

Registered

2018-07-16

Start date

2015-09-03

Completion date

2016-12-31

Last updated

2018-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy Generalized Idiopathic Not Intractable

Keywords

Generalized epilepsy, idiopathic, periodic limb movement

Brief summary

The study aimed to study the correlation between periodic limb movement occurring during sleep and the different parameters of genetic generalized epilepsy

Detailed description

Although periodic limb movements are prevalent among patients with epilepsy, the exact relationship between these movements and epilepsy remains elusive. Objective: The aim of this work was to study the periodic limb movements among patients with genetic generalized epilepsy in relation to different clinical characteristics and seizure recurrence. Methods: Sixty individuals participated in this study: thirty of them were newly diagnosed with genetic generalized epilepsy and thirty were healthy individuals. Sleep quality was assessed using the Pittsburgh Sleep Quality Index questionnaire, and a standard polysomnographic study was conducted to all subjects. All patients then received sodium valproate in therapeutic doses and were followed up for six months. Electroencephalogram (EEG) was done after the follow-up period and seizure recurrence was assessed. Accordingly, patients were classified into three groups according to clinical seizure recurrence and follow-up EEG findings. Periodic limb movement index and frequency were compared among the patients' groups and were correlated with different clinical characteristics.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

9 Years to 29 Years

Healthy volunteers

Yes

Inclusion criteria

* Newly diagnosed with genetic generalized epilepsy according to the ILAE 2010 criteria * did not previously receive AEDs. * The clinical seizures were either eyewitnessed by physicians or video-recorded to ensure they were true epileptic seizures. * At least two unprovoked seizures occurring \>24 hours apart

Exclusion criteria

* Patients with pre-existing psychiatric illnesses * Patients with seizures due to toxic or metabolic causes (including glucose disturbance, uremia, and electrolytes disturbance), infections, or structural causes (such as neoplasms) * Patients using hypnotic drugs

Design outcomes

Primary

Measure	Time frame	Description
Seizure recurrence	6 months	Clinical major or minor seizure, and electrical seizure

Outcome results