Ischemia, Myocardial, Ischemic Heart Disease
Conditions
Keywords
CFR, SPECT, CZT, Coronary, Calcium score, Scintigraphy, Myocardial perfusion
Brief summary
CFR has been studied for few years using 82 Rubidium PET (positron emission tomography) /CT. CFR has shown to be correlated with cardiovascular events occurring in the 10 following years. CFR also helps to identify multivessel coronary disease. Few studies have shown the possibility to calculate CFR during myocardial perfusion SPECT on new ultrafast CZT cameras.
Detailed description
Evaluate the contribution of CZT SPECT CFR in cardiovascular risk stratification: correlation with clinical scores, with calcium score, and when pathological with coronarography findings especially fractional flow reserve (FFR).
Interventions
DIAGNOSTIC_TESTCZT SPECT acquisition
CZT SPECT acquisition, with dynamic stress and rest acquisitions to calculate CFR If pathological, coronarography with FFR measurement if necessary In case of intermediate coronary stenosis with medical treatment, SPECT CFR evaluation after one year of treatment
Sponsors
Centre Hospitalier Régional d'Orléans
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients referred for myocardial ischemia screening
Exclusion criteria
* Patient already suffering from coronary disease with angioplasty, bypass surgery or myocardial infarction. * Contraindications related to the stress test: Acute Coronary Syndrome \<5 days Unstable angina Stenosis of left main artery untreated Uncontrolled severe rhythm disorders Uncontrolled heart failure * Contraindications to dipyridamole and regadenoson: Hypotension (systolic \<90mmHg) Severe pulmonary arterial hypertension Bradycardia \<40 beats / minute Sinusal Dysfunction and 2nd or 3rd degree Atrioventricular block Decompensated Heart Failure with Ejection Fraction \<25% Stenosis of supra-aortic trunks unilateral\> 70% or bilateral\> 50% Dipyridamole and regadenoson allergy * Patients with pacemaker, or who have had valvular surgery, * Well-known dilated cardiopathy * Pregnant or breastfeeding women, * Minor people * Persons under guardianship or under guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Regional and global CFR | Day 0 | Regional and global CFR calculated from CZT SPECT myocardial perfusion: correlation with clinical score and calcium score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| FFR Regional CFR after one year of medical treatment | Up to one year | FFR measured during coronarography if there is an intermediate stenosis Regional CFR if there is an intermediate coronary stenosis with medical treatment, after one year of treatment, calculated during a new SPECT CZT exam |
Countries
France
Outcome results
None listed