Brain Lesion, Cerebrovascular Disorders, Degenerative Disease, Developmental Disability
Conditions
Keywords
Neuropsychological study, Brain imaging
Brief summary
Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative/developmental disorders and selective cognitive disorders; (ii) healthy control subjects. The objective of this project is to evaluate specific neuropsychological deficits and apply current brain imaging techniques (anatomical, diffusion, functional, magnetic stimulation) to patients suffering from these cognitive deficits due to brain damage, in order to elucidate the brain mechanisms underlying these deficits.
Interventions
BEHAVIORALNeuropsychological testing
Experimental test about cognitive deficit of interest and standard neuropsychological tests
OTHERBrain Imaging
Anatomical, diffusion, and/or functional MRI
Stimulation versus Sham
Sponsors
University Hospital, Caen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age \> 17 years * French language * Effective contraception for women during the study * Informed consent * No alcohol intake the day before the exam * For patients only, focal cerebral lesion (stroke, malformation, tumor, inflammatory, infectious, traumatic), neonatal pathology, developmental or degenerative disease with cognitive deficit
Exclusion criteria
* For healthy volunteers: previous neurological history (except non complicated migraine or epilepsy), previous psychiatric history (except depression with good evolution or anxiety), or severe cranial traumatism * For patients: vigilance disorders, severe depression or anxiety. * For both: psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month, severe visual or auditory impairment, patient without judicial or administrative liberty, measure of legal protection or no capable to express their consent, pregnancy or breastfeeding, contraindication for MRI or GVS if applicable, participation in another trial or former involvement in another trial within one month.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive Deficit | 3 months to more than 2 years | The cognitive deficit of interest will depend on the localization of the brain lesion. The outcome measure could be a standardized neuropsychological test or an experimental test specifically elaborated for this protocol. |
Countries
France
Contacts
CONTACTOlivier MARTINAUD, MD, PhD
PRINCIPAL_INVESTIGATOROlivier MARTINAUD, MD, PhD
Caen University Hospital, Normandie UNIV, UNICAEN, PSL Research University, EPHE, Inserm, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000 Caen, France
Outcome results
None listed