Macular Retinoschisis, Retinal Disease
Conditions
Brief summary
High myopic schisis (HMF) has the clinical feature of separation between retinal layers. It is sometimes accompanied with foveal retinal detachment, macular lamellar hole, epiretinal membrane and vitreous retraction. HMF may develop to macular hole, macular detachment and will damage the visual function. Pars plana vitrectomy (PPV) is a commonly used surgery in the treatment of HMF. PPV together with internal limiting membrane (ILM) peeling and long-term gas tamponade was reported to be safe and effective. But nowadays there was no available long-term gas in our country. Also, whether ILM peeling is necessary remains controversial, Indole cyanine green (ICG)was proved to have potential toxicity to the retina and the ILM peeling has the risk of causing secondary macular hole. We propose to make a prospective nonrandomized controlled study to evaluate the safety and efficiency of using PPV alone in the treatment of HMF.
Interventions
PROCEDUREPars plana vitrectomy
pars plana vitrectomy without ICG staining and ILM peeling
Sponsors
Aier School of Ophthalmology, Central South University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. Patients diagnosed as high myopic macular retinoschisis, with axial length more than 26.5mm. 2. Morphologic manifestation in OCT shows split between retinal layers in macular area. 3. Patients without severe systemic disease and can tolerate surgery.
Exclusion criteria
1. Patients also have other ocular disease, including glaucoma, keratitis,uveitis, retinal detachment,etc. 2. Patients with nystagmus or have difficult to open the eye. 3. Patients with severe systemic disease and cannot tolerate surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The morphologic change of macular area | OCT will be done one day before surgery and one week, one month, three months and six months after surgery | The thickness of the macular fovea in optical coherence tomography (OCT) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The best corrected visual acuity (BCVA) change | One day before surgery and one week, one month, three months and six months after surgery | The BCVA of all involved patients |
| The best corrected near visual acuity (BCNVA) change | One day before surgery and one week, one month, three months and six months after surgery | The BCNVA of all involved patients |
| The visual function change | One day before surgery and one week, one month, three months and six months after surgery | The contrast sensitivity of all involved patients |
Countries
China
Contacts
Primary ContactZhuyun Qian, Doctor
Backup ContactWensheng Li, Doctor
Outcome results
None listed