Liver Cancer, Liver Neoplasms
Conditions
Keywords
Liver Cancer, laparoscopic hepatectomy, open hepatectomy
Brief summary
This study was divided into laparoscopic hepatectomy (observation group) and laparoscopic hepatectomy (control group).Compared two groups of age, sex, body mass index (BMI), tumor diameter, number of tumors (single/multiple), pathologic characteristics, HBsAg (positive/negative), liver function, AFP, Child - Pugh, grading, nursing method and comparison of two groups of patients after surgery (surgical incision length, intraoperative blood, intraoperative blood transfusion and transfusion volume, operation time) the number of cases of and postoperative rehabilitation (death cases, for the first time the meal time, anus exhaust time, analgesic bed, first time, the abdominal cavity drainage tube time, length of hospital stay, postoperative days and liver function index.Follow-up: the survival rates of the two groups were compared in six months, one year, two years, three years and five years.In this study, the initial selection of the minimum sample size of 30 cases, plus 20% inefficiencies, the final initial selection of 36 cases, and the later expansion of the sample size of 100 cases.The research date starts on October 1, 2017.
Detailed description
Research design and methods: This study was divided into laparoscopic hepatectomy (observation group) and laparoscopic hepatectomy (control group).Compared two groups of age, sex, body mass index (BMI), tumor diameter, number of tumors (single/multiple), pathologic characteristics, HBsAg (positive/negative), liver function, AFP, Child - Pugh, grading, nursing method and comparison of two groups of patients after surgery (surgical incision length, intraoperative blood, intraoperative blood transfusion and transfusion volume, operation time) the number of cases of and postoperative rehabilitation (death cases, for the first time the meal time, anus exhaust time, analgesic bed, first time, the abdominal cavity drainage tube time, length of hospital stay, postoperative days and liver function index.Follow-up: the survival rates of the two groups were compared in six months, one year, two years, three years and five years.In this study, the initial selection of the minimum sample size of 30 cases, plus 20% inefficiencies, the final initial selection of 36 cases, and the later expansion of the sample size of 100 cases. Statistical methods: by means of SPSS 23.0 to analyze the data, all data after the normal test to choose the appropriate statistical methods, the normal distribution of measurement data in the two groups use surgery and postoperative recovery using two sets of samples t test, liver function index using analysis of variance, non-normal distribution using nonparametric test, count data chi-square test, P \< 0.05 for the difference was statistically significant.Survival analysis was performed on two groups of patients.The research date starts on October 1, 2017.
Interventions
PROCEDURElpaparoscopic hepatectomy
laparoscopic hepatectomy： laparoscopic hepatectomy for hepatocellular carcinoma.
PROCEDUREopen hepatectomy
open hepatectomy: open hepatectomy for hepatocellular carcinoma
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Hepatocellular carcinoma There was no distant metastasis in patients with malignant tumors.
Exclusion criteria
primary tumor diameter \> 10cm Thrombosis of portal or inferior vena cava carcinoma Severe organic disease or cirrhosis of the liver Laparoscopic transposition of the abdomen Concomitant coagulant function abnormal patient.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of complications of primary liver cancer treated by laparoscopic hepatectomy and laparoscopic hepatectomy,The questionnaire survey | Patients with hepatocellular carcinoma who were hospitalized together on October 1, 2017 were studied at the time point before discharge. | The incidence of complications, in percent |
| The survival rate of primary liver cancer treated by laparoscopic hepatectomy and laparoscopic hepatectomy,Telephone pays a return visit | 1 month after discharge | Survival rate, percent |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of the number of replacement drainage bags for primary hepatocellular carcinoma between laparoscopic hepatectomy and laparoscopic hepatectomy, unit: number | Patients with liver cancer who are hospitalized on 1 October 2017 will be included in the study date.The study time is 1 year. | Compare the number of times to replace the drainage bag, unit: number |
| Comparison of infusion days between laparoscopic hepatectomy and laparoscopic hepatectomy for primary liver cancer Unit: day | Patients with liver cancer who are hospitalized on 1 October 2017 will be included in the study date.The study time is 1 year. | Infusion days, unit: days |
| Comparison of oxygen uptake days between laparoscopic hepatectomy and laparoscopic hepatectomy for primary liver cancer, unit: day | Patients with liver cancer who are hospitalized on 1 October 2017 will be included in the study date.The study time is 1 year. | Oxygen uptake days, per day |
| Comparison between laparoscopic hepatectomy and laparoscopic hepatectomy in primary hepatocellular carcinoma Unit: times | Patients with liver cancer who are hospitalized on 1 October 2017 will be included in the study date.The study time is 1 year. | Number of subcutaneous injections Unit: times |
| Comparison of muscle injection times between laparoscopic hepatectomy and laparoscopic hepatectomy in primary liver cancer: times | Patients with liver cancer who are hospitalized on 1 October 2017 will be included in the study date.The study time is 1 year. | Muscle injections,Unit: times |
| Comparison of ecg monitoring days between laparoscopic hepatectomy and laparoscopic hepatectomy for primary liver cancer Unit: day | Patients with liver cancer who are hospitalized on 1 October 2017 will be included in the study date.The study time is 1 year. | Guardianship days, unit: days |
Countries
China
Contacts
Primary ContactZeng Li
Backup ContactYe Lin
Outcome results
None listed