Acne Vulgaris, Diet Modification
Conditions
Keywords
Acne Vulgaris, Low Glycemic Diet, Doxycycline, Adapalene
Brief summary
Clinical trial to determine the effect of adding a diet with low glycemic index and load to adults for the treatment of moderate acne. Adult patients with acne where recruited in two groups, A and B. Group A received a normal diet according to their metabolic status and group B received a diet with low glycemic index and load. Outcomes were measured at week 12.
Detailed description
Clinical trial to determine the effect of adding a diet with low glycemic index and load to adults for the treatment of moderate acne. Adult patients with acne where recruited in two groups, A and B. Both groups of treatment were treated with doxycycline 100 mg per day plus adapalene 0.1% gel daily for 12 weeks. During pharmacologic treatment, all patients had nutrition counseling monthly. Group A received a normal diet according to their metabolic status and group B received a diet with low glycemic index and load. At the end of the trial, the change in acne lesions count was analyzed and also their metabolic status. Quality of life was also measured.
Interventions
OTHERNormal diet
The energy consumption of each of the participants will be calculated, using the Mifflin-St Jeor formula. Each participant will receive a standard menu of 6 days according to their metabolic requirements and a list of equivalent foods. The distribution of macronutrients will be: 45% carbohydrates, 30% lipids and 25% proteins.
OTHERLow glycemic diet
The energy consumption of each of the participants will be calculated, using the Mifflin-St Jeor formula. Each participant will receive a standard menu of 6 days according to their metabolic requirements and a list of equivalent foods. A list of foods classified as having low index and glycemic load was used according to the mexican equivalent food system. The distribution of macronutrients will be: 45% carbohydrates, 30% lipids and 25% proteins. Milk and vitamin supplements will be eliminated from the diet.
Adapalene 0.1% gel daily at night for 12 weeks, applied on the face, chest and back.
DRUGDoxycycline
Doxycycline 100 mg per day orally, before breakfast
Sponsors
Centro Dermatológico Dr. Ladislao de la Pascua
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Masking description
Diet intervention was made by the nutrition specialist. Neither the principal investigator nor the outcome assessor were aware about the group of diet intervention.
Intervention model description
Randomized clinical trial, two-arm
Eligibility
Sex/Gender
MALE
Age
18 Years to 25 Years
Healthy volunteers
No
Inclusion criteria
* Having moderate inflammatory acne * 18 to 25 years old * Male * Stable weight during the last 3 months
Exclusion criteria
* Previous or actual isotretinoin therapy * Antibiotic therapy or during the last 3 months * Therapy based on peelings, dermabrasion, laser or intense pulsed light during the last 6 months * Endocrine disorders * Drug and alcohol consumption during the last 6 months * Tabacco use during the last 6 months * Lactose intolerance * Have eating disorders or gastrointestinal disorders * Actual nutrition therapy * Have chronic diseases that requires pharmacologic therapy * Severe acne that requires isotretinoin therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Count of inflammatory acne lesions | 12 weeks | Number of papules and pustules |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Count of non-inflammatory acne lesions | 12 weeks | Number of comedones |
| Changes in quality of life | 12 weeks | Score of the Dermatology Life Quality Index |
Outcome results
None listed