Mucoviscidosis Involving the Lung
Conditions
Brief summary
The goal of this study is to implement a non-invasive version of the sweat secretion test based in visualization of sweat glands following β-adrenergic stimulation of sweat. Specifically, the trial will evaluate the relative response of sweat glands to β-adrenergic and cholinergic stimulation among participants with CF, heterozygous and matched control subjects
Interventions
DIAGNOSTIC_TESTIontophoresis sessions in forearm of subjects with pilocarpine
The test with two iontophoresis sessions is performed in a forearm of subjects. Pilocarpine is applied during the first iontophoresis session to evoke cholinergic-induced sweat secretion. Atropine, isoprenaline and aminophylline are applied during the second iontophoresis session, to block the cholinergic component and to evoke β-adrenergic-induced sweat secretion.
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
Intervention Model: Three Group Assignment
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* For patients with cystic fibrosis: clinically stable, all genotypes included. * For healthy volunteer and heterozygous subjects: 18 years and older.
Exclusion criteria
* Corticosteroids, anti-leukotriene therapy, unstable clinical status, \<40% FEV1. * Current pregnancy or breastfeeding.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ratio between the β-adrenergic/cholinergic rate | up to 30 minutes | The ratio between the β-adrenergic/cholinergic rate (nL/min) of droplets of sweat is calculated. |
Countries
Belgium
Contacts
Primary ContactTeresinha LEAL, Biologist
Backup ContactAudrey REYNAERTS, Sciences
Outcome results
None listed