Insulin- and Glucose Metabolism in Pulmonary Arterial Hypertension

Insulin- and Glucose Metabolism in Pulmonary Arterial Hypertension - a Pilot Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03584607

Enrollment

Registered

2018-07-12

Start date

2017-12-20

Completion date

2019-02-11

Last updated

2020-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Insulin Resistance

Brief summary

Insulin resistance is a key mechanism in metabolic disorders, which has also been implicated in the development of pulmonary hypertension. In this pilot study, the investigators´ goal is to directly determine insulin sensitivity in idiopathic pulmonary arterial hypertension patients and to compare the results with data from healthy controls.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Yes

Inclusion criteria

* signed informed consent form * patients with idiopathic or hereditary pulmonary hypertension / healthy controls

Exclusion criteria

* premenopausal women * other relevant lung disease * relevant left heart disease * untreated systemic hypertension * Diabetes mellitus * pulmonary hypertension other than idiopathic or hereditary form

Design outcomes

Primary

Measure	Time frame	Description
Insulin resistance	1 day	Determination of insulin sensitivity using hyperinsulinemic-euglycemic clamp technique

Countries

Austria

Outcome results