Skeletal Muscle Parameters of Liver Cirrhosis in Non-invasive Imaging and Outcome

Conditions

Liver Cirrhosis

Keywords

sarcopenia, cirrhosis, transjugular intrahepatic portosystemic shunt, TIPS, acute-on-chronic liver failure, ACLF

Brief summary

The principal aim of this study is to analyse L3-SMI (skeletal muscle index) in a cohort of patients with decompensated liver cirrhosis and TIPS (transjugular intrahepatic portosystemic shunt), and compare the prognostic power with TPMT (transverse psoas muscle thickness). Furthermore, the role of myosteatosis, determined in CT by L3-SMI, MRI and ultrasound will be studied.

Detailed description

The principal aim of this study is to analyse L3-SMI (skeletal muscle index) in a cohort of patients with decompensated liver cirrhosis and TIPS (transjugular intrahepatic portosystemic shunt), and compare the prognostic power with TPMT (transverse psoas muscle thickness). Furthermore, the role of myosteatosis, determined in CT by L3-SMI, MRI and ultrasound will be studied.

Praktiknjo M, Zhou T, Krüsken M, Jacob T, Sprinkart AM, Nowak S, Kimmann M, Dold L, Chang J, Jansen C, Strassburg CP, Luetkens J, Weismüller TJ.

2023-08-144 citations

10.1016/j.dld.2023.08.037

Combination of Fat-Free Muscle Index and Total Spontaneous Portosystemic Shunt Area Identifies High-Risk Cirrhosis Patients

Anton Faron, J Abu-Omar, Johannes Chang, N Böhling, Alois M. Sprinkart et al. (13 authors)

Frontiers in Medicine2022-04-129 citations

10.3389/fmed.2022.831005

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum et al. (16 authors)

PLoS ONE2019-10-238 citations

10.1371/journal.pone.0222840

Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt

Michael Praktiknjo, Caroline Clees, Alessandra Pigliacelli, Stefan Fischer, Christian Jansen et al. (14 authors)

Clinical and Translational Gastroenterology2019-03-29119 citations

10.14309/ctg.0000000000000025

Interventions

DIAGNOSTIC_TESTimaging

computed tomography, magnetic resosnance imaging, ultrasound

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

No

Inclusion criteria

* liver cirrhosis of any etiology * CT scan available

Exclusion criteria

* HCC or any malignant disease

Design outcomes

Primary

Measure	Time frame	Description
Survival time	up to 60 months	time of survival

Secondary

Measure	Time frame	Description
Time to clinical acute decompensations	up to 60 months	time to occurrence of acute decompensations of liver cirrhosis (readmissions, hepatic encephalopathy, bleeding, ascites, hepatorenal syndrome, infections)
Time to clinical acute-on-chronic liver failure	up to 60 months	acute-on-chronic liver failure according to EASL-CLIF-C definition (grade 1 (best) to 3 (worst)
Development of sarcopenia	up to 60 months	Assessment of sarcopenia according to EASL-guideline

Countries

Germany, Italy

Contacts

Primary ContactMichael Praktiknjo, MD

michael.praktiknjo@ukbonn.de+49228 287 15770

Backup ContactJohannes Chang, MD

johannes.chang@ukbonn.de+49228 287 15770

Outcome results

None listed