Complement System; Disorder, Diabetic Pregnancy, Pregnancy Related
Conditions
Keywords
Diabetic pregnancies, Factor XII
Brief summary
To compare Factor XII levels in gestational diabetic and healthy pregnancies.
Detailed description
Thirty singleton term pregnant women with a diagnosis of Type I, Type II or gestational diabetes and thirty singleton uncomplicated term healthy pregnant women will be included in our study. Our study will be performed at Istanbul Acibadem Maslak Hospital, Turkey. Blood will be drawn from each patient when they are hospitalized and before they deliver either vaginally or by cesarean section. Blood will be drawn into two citrate tubes, each will contain 4 ml blood. Blood will be transferred to the lab immediately and will be centrifuged. The supernatant will be stored at -80°C. When the anticipated number of samples are completed Factor XII levels will be calculated in each sample.
Interventions
DIAGNOSTIC_TESTDiabetic pregnancy
Blood samples will be drawn before delivery to evaluate Factor XII level.
DIAGNOSTIC_TESTNon-diabetic pregnancy
Blood samples will be drawn before delivery to evaluate Factor XII level.
Sponsors
Acibadem University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Term pregnancy * Pregnant patients with a diagnosis of Type I diabetes * Pregnant patients with a diagnosis of Type II diabetes * Pregnant patients with a diagnosis of Gestational diabetes * Non-diabetic pregnancies * Uncomplicated pregnancies
Exclusion criteria
* Preterm pregnancy * Postterm pregnancy * Pregnant patients with a diagnosis of systemic diseases other than diabetes * Complicated pregnancies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Factor XII level | Blood will be drawn when the patient is hospitalized before they deliver. | The primary outcome is to evaluate Factor XII level in diabetic pregnancies. If the investigators can prove that Factor XII, which has a mitogenic activity and can increase the risk for thrombosis, increases more in diabetic pregnancies in the future usage of Factor inhibitors may reduce macrosomia, thrombosis and the complications due to these conditions in diabetic pregnancies |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Macrosmia | Blood will be drawn when the patient is hospitalized before they deliver. | The secondary outcome is to prove that the increase of Factor XII level is higher diabetic pregnancies and this increase might have an effect on macrosomia. |
Countries
Turkey (Türkiye)
Outcome results
None listed