Acquired Immunodeficiency Syndrome, Drug Dependence, Human Immunodeficiency Virus, Opiate Addiction
Conditions
Keywords
HIV, AIDS, Opiate Addiction, Drug Dependence, Buprenorphine
Brief summary
STRIDE2 is a longitudinal, non-randomized study of individuals living with HIV who are dependent on opioids. This study is funded by the National Institute on Drug Abuse (R01DA030768, Altice, PI; Taxman & Lawson, Co-PIs) and is being conducted by George Mason University, Yale University, and Howard University.
Detailed description
STRIDE2 will assist in identifying and monitoring individuals' HIV risk behaviors and provide resources to seek treatment for their HIV care and substance use. The goal of STRIDE2 is to examine if there are differences in HIV, drug use, and other outcomes between individuals receiving treatment versus individuals actively using, not actively using and not in treatment, and individuals on Methadone, Suboxone, or in some other treatment.
Interventions
DRUGbuprenorphine
To provide buprenorphine for 12 months for those who are interested in receiving it.
Sponsors
National Institute on Drug Abuse (NIDA)
George Mason University
Howard University
Yale University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. HIV+, confirmed by rapid HIV test 2. Meet DSM-IV criteria for opioid dependence 3. 18 years or older 4. Have health insurance that is accepted at Lab Corp.
Exclusion criteria
1. Are \<18 years old; 2. Are HIV negative; 3. Are Unable to communicate in English; 4. Are not able to provide informed consent; 5. Do not meet DSM-IV criteria for opioid dependence; 6. Plan to leave the DC area
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CD4+ cell count | Month 0 | Blood test for HIV CD4+ cell count |
| VL <400 | Month 0 | Blood test for HIV viral load |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Retention in HIV care | Month 0 | Survey data for retention |
| Medically assisted therapy retention | Month 0 | Measure of length of time on Methadone or Buprenorphine |
| Opioid use | Month 0 | Measure of relapse to opioid use |
| HIV risk behaviors | Month 0 | Survey for HIV risks |
Other
| Measure | Time frame | Description |
|---|---|---|
| Reincarceration | Month 0 | Measure of rearrest and reincarceration |
Countries
United States
Outcome results
None listed