Premature Ejaculation
Conditions
Brief summary
Lifelong premature ejaculation (LPE) is a common male sexual dysfunction with a high prevalence in global. Up to now, the etiology of LPE remains unclear. In recent years, dapoxetine, a highly potent serotonin-transporter inhibitor, has been used for treating premature ejaculation. However, the underlying mechanism of dapoxetine was unknown. Recently, with widespread use of neuroimaging techniques, like positron emission tomography and magnetic resonance imaging (MRI) in basic science, researchers can acquire human data on cerebral base of human sexual behavior, not only in normal subjects but also in patients with sexual dysfunction. Therefore, in order to further understand the biological mechanism of LPE and the brain targets of dapoxetine, the present study would investigate the brain changes of LPE and the effect of dapoxetine on brain activation by using MRI technology.
Interventions
DRUGDapoxetine Hydrochloride Tablet
oral one dapoxetine hydrochloride tablet before MRI scan
DRUGPlacebo Tablet
oral one placebo tablet before MRI scan.
Sponsors
Xidian University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
* right-handed male Chinese volunteers * intravaginal ejaculatory latency time within 1 min * premature ejaculation diagnostic tool score \>11 for patients, but \<5 for each control. * patients who never received dapoxetine hydrochloride or other SSRI drugs
Exclusion criteria
* smokers * had medical，neurological or psychiatric disorders * had alcohol, nicotine, or drug abuse * received any treatment at least 2 weeks before the experiment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Resting-state brain function measured by Functional magnetic resonance imaging | One day | We will use several indicators to assess the resting-state brain function based on fMRI analysis, including regional homogeneity,Amplitude of Low Frequency Fluctuations, and functional connectivity. |
Countries
China
Contacts
Primary Contactxuejuan Yang
Outcome results
None listed