Eosinophilic Esophagitis (EoE)
Conditions
Keywords
EoE, Dysphagia
Brief summary
Is there a difference in the eating process for patients with active Eosinophilic Esophagitis (EoE) and those with inactive disease?
Detailed description
Eosinophilic esophagitis (EoE) patients develop adapted eating behaviors to prevent symptoms. These patients tend to cut their food small, chew extensively, take copious liquids with meals, and avoid foods that cause symptoms. No studies to date have directly evaluated these eating behaviors in patients with EoE with observation. Furthermore, none of the investigators' current metrics for patient symptom assessment visually evaluate the eating process nor are they compared before and after treatment. As a result, it is unclear if a patient's subjective perception of their eating difficulties and improvement matches with objective measures.
Interventions
BEHAVIORALObserved eating session
Eating a Jimmy Johns turkey or vegetarian sandwich
Sponsors
Mayo Clinic
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 18 years of age and older * Patients suspected to have Eosinophilic Esophagitis * Patients being treated for EoE with PPI or a steriod * EoE patients that are in remission by having less than 22 on the EEsAI questionnaire * Controls, patients that do not have EoE or other swallowing issues
Exclusion criteria
* Clinical evidence of infectious process potentially contributing to dysphagia (candidiasis, CMV,herpes) * Other cause of dysphagia identified at endoscopy (reflux esophagitis, stricture, web, ring, achalasia, esophageal neoplasm) * EoE patients that do not eat sandwiches or feel they could not eat a sandwich.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Observed eating session | 15-90 minutes | number of bites of patient's with EoE and controls eating a Jimmy John's sandwich |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Food slowness during eating session | 15-90 minutes | number of bites that felt stuck among patients with EoE and controls when eating a Jimmy John's sandwich |
| Water during eating session | 15-90 minutes | amount of water drank of patients with EoE and controls eating a Jimmy John's sandiwch |
| Eosinophilic Esophagitis activity Index (EEsAI) questionnaire | 10-15 minutes | The EEsAI Pro uses the VDQ is visual dysphagia question AMS is avoidance, modification, slow eating question . These two along with questions on frequency of, duration of, pain associated with dysphagia make up the PRO (patient reported outcomes). The PRO is a number (0-100) calculated from the answer to the questions. A PRO \< 20 defines asymptomatic EoE. |
| Eosinophilic Esophagitis Quality of Life questionnaire | 10-15 minutes | Higher score denote better quality of life. 0-4 as follows 4=not at all, 3=Slightly 2=moderately, 1=Quite a bit, 0= Extremely |
Countries
United States
Outcome results
None listed