Cycling Exercise in Mechanical Ventilation

Effect of a Cycling Exercise on Restoration of Muscle Strength in Patients Undergoing Mechanical Ventilation

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03581760

Enrollment

120

Registered

2018-07-10

Start date

2017-05-02

Completion date

2020-12-31

Last updated

2022-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Weakness, Mechanical Ventilation Complication

Keywords

cycling exercise, mechanically ventilated patient, muscle strength assessment, muscle weakness

Brief summary

Prolonged critical illness renders survivors with increased long-term morbidity associated with high healthcare costs. Muscle weakness and fatigue are reported as the main contributors to long-term poor functional outcomes. Emerging evidence for early mobilisation demonstrates reduction in the number of ventilator days and hospital length of stay. It has been demonstrated that daytime motoring (passive and active) can improve functional capacity in intensive care patients. The aim of the proposed study is to evaluate the effect of cycling exercise in patients on mechanical ventilation appointed to weaning process.

Detailed description

This prospective randomized study is being performed at the Department of Anesthesiology, Resuscitation and Intensive Care (CARIM) of the University Hospital Ostrava. All mechanically ventilated patients are followed. At the time of weaning initiation, the randomization into two groups (the study (cycling) and control group) is performed. The physiotherapy will be carried out twice a day in both groups according to the mobility protocol. The cycling exercise is performed only in the study group, once a day. Before a patient is released from the ICU, a cycling test, dynamometry test will be performed on both groups.

Interventions

OTHERCycling Exercise

Cycling exercise will be performed in the patients once a day.

OTHERConventional Physiotherapy

Conventional physiotherapy will be performed in the patients twice a day.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Masking description

This is an open-label study, no masking model is applied.

Intervention model description

Patients enrolled in the study will be randomized into two groups - active intervention and control group.

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \> 18 years * ICU admission * Mechanically ventilated for more than 5 days * Indications for starting weaning * Informed consent for participation

Exclusion criteria

* Inability to use cycling exercise: trauma or operation of lower limbs, pelvis, open abdomen, non-cooperation (qualitative and quantitative disturbance of consciousness) * Encephalopathy (ischemic, traumatic) * Extreme obesity (body mass index ≥ 40) * Anticipated survival time ≤ 7 days * Patient height ≤ 1.5 m * More than 48 hours of mechanical ventilation outside of the department

Design outcomes

Primary

Measure	Time frame	Description
Number of ventilator days	43 months	The influence of cycling exercises on the number of ventilator days will be assessed in the patients. The number of ventilator days will be compared in both groups of patients.

Secondary

Measure	Time frame	Description
Muscle strength	43 months	Muscle strength will be assessed in the mechanically ventilated patients in both groups on the Medical Research Council Manual Muscle Testing scale. This muscle scale grades muscle power on a scale of 0 to 5 in relation to the maximum expected for that muscle; the higher the measured value, the bigger the muscle strength and vice versa.

Countries

Czechia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026