Hypertension, Pulmonary
Conditions
Brief summary
To investigate if the inflammatory protein, high mobility group box 1 (HMGB1), along with other inflammatory mediators, is elevated in pediatric patients with congenital heart disease (CHD) and pulmonary hypertension as compared to those with CHD alone, or with healthy controls.
Interventions
OTHERBlood test
Blood test
Sponsors
The Hospital for Sick Children
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 18 Years
Healthy volunteers
Yes
Inclusion criteria
-patients of any age with congenital cardiac disease coming for catheterization of the right heart, or both the right and left heart.
Exclusion criteria
* active systemic infection * current active cancer * active cancer treatment * prior bone marrow transplant * prior solid organ transplant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of HGMB1 | 1 day | Measurement of HGMB1 |
Countries
Canada
Contacts
PRINCIPAL_INVESTIGATORKatherine Taylor
The Hospital for Sick Children
Outcome results
None listed