Primary Failure of Eruption
Conditions
Brief summary
The primary purpose of the study is to identify clinical, radiological and genetic diagnostic criteria for Primary Failure of Eruption (PFE). The secondary purposes are to highlight the genotype-phenotype correlations in the PTHR1 and non-PTHR1 forms and analyze the therapeutic failures.
Interventions
GENETICgenetic analysis
saliva is collected for DNA extraction
RADIATIONpanoramic radiography
panoramic radiography
RADIATIONteleradiography
teleradiography
RADIATIONintraoral X-rays
intraoral X-rays
RADIATIONCT scan of maxillary and mandible
CT scan of maxillary and mandible
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
single group
Eligibility
Sex/Gender
ALL
Age
6 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* people over 6 years old * people with Primary Failure Eruption
Exclusion criteria
* children under 6 years old * endocrine pathology that may interfere with dental eruption * rickets * chemotherapy / radiotherapy * bisphosphonate treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Swallowing | at inclusion (day 1) | Assessment of swallowing by lingual interposition |
| Chewing | at inclusion (day 1) | Assessment of chewing by Plana's Functional Masticatory Angles (PFMA) |
| Nasal breathing | at inclusion (day 1) | Assessment of nasal breathing by the Rosenthal's test |
| Number of teeth | at inclusion (day 1) | number of teeth |
| Recording of dental caries | at inclusion (day 1) | recording of dental caries by Decayed Missing Filled Teeth index (DMFT index) |
| Recording the location of dental caries | at inclusion (day 1) | the number of teeth affected using the international classification index |
| Drugs intra uterine exposure | at inclusion (day 1) | drugs during pregnancy |
| Nutritional deficiencies | at inclusion (day 1) | nutritional deficiencies assessed by a questionnaire |
| Periodontium | at inclusion (day 1) | assessment of the periodontium by Maynard and Wilson classification |
| Oral hygiene | at inclusion (day 1) | assesment of oral hygiene by plaque index (Löe and Silness, 1963) |
| Gingival inflammation | at inclusion (day 1) | assesment of gingival inflammation by gingival index (Löe and Silness, 1963) |
| Treatment needs | at inclusion (day 1) | assessment of treatment needs using Community Periodontal Index of treatment Needs (CPITN) |
| Face shape | at inclusion (day 1) | assesment of the face shape : round, square, oval |
| Symmetry of the face | at inclusion (day 1) | symmetry of the face (yes/no) |
| Profile (shape) | at inclusion (day 1) | assessment of the profile (shape) |
| Smile | at inclusion (day 1) | morphology of the smile |
| Vertical dimension | at inclusion (day 1) | assessment of the vertical dimension: anterior infraclusion or overbite (in %) |
| Transversal dimension | at inclusion (day 1) | assessment of the transversal dimension: posterior transversal dimension (in mm) |
| Sagittal dimension | at inclusion (day 1) | Assessment of the sagittal dimension by Angle's classification |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Type of treatment performed | at inclusion (day 1) | (orthodontics, surgery, prothesis) |
| Mutations causing PFE | at inclusion (day 1) | — |
Countries
France
Contacts
Primary ContactMarion STRUB, Doctor
Outcome results
None listed