LUF - Luteinised Unruptured Follicle Syndrome
Conditions
Keywords
LUF, HCG, Booster dose, Ovulation rate, pregnancy rate
Brief summary
This study will be conducted to assess the effect of booster dose of hCG on the unruptured follicles in non IVF/ICSI cycles.
Detailed description
In this study enrolled patients (n=160) who underwent controlled ovarian stimulation and timed intercourse with unruptured mature graffian follicle 48 hours after IM 10,000 IU HCG dose. Patients were allocated randomly into intervention group and control group. In the intervention group another booster dose (10,000 IU of hCG) was given IM while in the control group 2 ml normal saline was given IM leaving follicles for spontaneous rupture
Interventions
DRUGhCG
A booster dose (10,000 IU of hCG) was given IM 48 hours after first triggering dose
DRUGSaline Solution
2 ml of normal saline will be injected 48 hours after first triggering dose
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Masking description
Double blinded
Intervention model description
Cohort groups with parallel allocation
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Ordinary stimulated cycles * IUI stimulated cycles * Unruptured follicle after 10000 IU IM HCG triggering
Exclusion criteria
* IVF/ICSI cycles
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ovulation rate | 48 hours | rupture of dominant follicle manifested by disappearance of follicle and presence of free fluid in douglas pouch |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pregnancy rate | 15 days | Number of cases with positive serum pregnancy test |
Countries
Egypt
Outcome results
None listed