Coronary Artery Disease, Ticagrelor
Conditions
Keywords
Ticagrelor, Clopidogrel, Switching strategy
Brief summary
The study is to further exploring the optimal switching strategy by evaluating the pharmacodynamic responses as well as adverse events in patients with complexity of coronary artery disease managed by percutaneous coronary intervention (PCI). All participants will be divided into three groups and recieving ticagrelor 90mg plus aspirin 100mg at 12 hours after the last dose of clopidogrel; recieving ticagrelor 90mg plus aspirin 100mg at 24 hours after the last dose of clopidogrel; recieving ticagrelor 180mg plus aspirin 100mg at 24 hours after the last dose of clopidogrel.
Interventions
DRUGTicagrelor
Ticagrelor, 90mg, 90mg twice daily
Sponsors
Shenyang Northern Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Age between 18-75 2. Patients with complexity of CAD determined by coronary angiography and implanted stent successfully 3. Taking clopidogrel 75mg daily over 5 days or paients never took clopidogrel previously should receive 300-600mg drugs at least 12 hours before coronary angiography 4. Agreeing to participate in this trial and signed the written informed consent.
Exclusion criteria
1. They contraindicated with ticagrelor (including: allergying to ticagrelor or its active metabolite 2. Concomitanting therapy with a strong cytochrome P-450 3A inhibitor or inducer 3. Previous intracranial haemorrhage or ongoing bleeds 4. Moderate or severe hepatic impairment) 5. Having a previous medication with ticagrelor or long term anticoagulation 6. Having a history of asthma or chronic obstructive pulmonary disease (COPD) and recurrent attacked 7. Having an uncontrolled hypertension\>180/110mmHg 8. Having a hemoglobin\<100g/L 9.Having a platelet counts\<100×10\^9/L 9. Having severe renal impairment (clearance\<30mL/min) 10. Having a history of hepaein-induced thrombocytopenia (HIT) 11. Having a pregnancy or were during lactation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Platelet function assessments | 7 Days | The primary endpoint was the comparations between the three projects for the value changes of maximal platelet aggregation (MPA) measured by Light Transmittance Aggregometry (LTA) at 2 hours after switching strategies. |
Countries
China
Outcome results
None listed