Healthy
Conditions
Brief summary
Effects of GLP-2 and GIP on bone remodeling in healthy young men.
Detailed description
We will investigate acute effects of GLP-2 and GIP on bone remodeling in healthy young men.
Sponsors
Hvidovre University Hospital
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Age between 20 and 40 years old Caucasian Healthy BMI between 18.5 and 24.9 kg/m2.
Exclusion criteria
Chronic disease Smoking Medication Weight change more than 3 kg whitin the last 3 months Overweight surgery Intestinal surgery Hgb\<8,0 mmol/L Decreased renal function.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bone resorption | From -10 minutes to 240 minutes. | C-terminal telopeptide (CTX) is a marker of bone resorption. Measured in serum. |
| Bone formation | From -10 minutes to 240 minutes. | P1NP is a marker of bone formation. Measured in serum. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Calcium | From -10 minutes to 240 minutes. | Measured in serum. |
| GIP | From -10 minutes to 240 minutes. | Intact and total GIP. |
| GLP-2 | From -10 minutes to 240 minutes. | Intact GLP-2 |
| Insulin | From -10 minutes to 240 minutes. | Measured in serum. |
| C-peptide | From -10 minutes to 240 minutes. | Measured in serum. |
| Sclerostin | From -10 minutes to 240 minutes. | Bone marker. |
| Glucose | From -10 minutes to 240 minutes. | Measured in serum. |
| Parathyroid hormone | From -10 minutes to 240 minutes. | PTH is a bone marker |
Other
| Measure | Time frame | Description |
|---|---|---|
| Heart rate | From -10 minutes to 240 minutes. | Before blood sampling |
| Blood pressure | From -10 minutes to 240 minutes. | Before blood sampling |
Countries
Denmark
Outcome results
None listed