Ankle Osteoarthritis, Bleeding, Knee Osteoarthritis, Tranexamic Acid
Conditions
Brief summary
Tranexamic acid has been shown to be effective in reducing blood loss and transfusion in orthopedic surgery. It remains unknown the ideal therapeutic regimen. The goal of this study is to compare 3 dosage regimen of tranexamic acid in patients submitted to major orthopedic surgery.
Detailed description
There is ongoing debate, however, around optimal perioperative tranexamic acid dosing, which varies widely. A large number of studies comparing tranexamic acid to placebo, overall blood loss and transfusion requirements are both reduced by ≈30%. A well designed tranexamic acid trial will provide answers to the best regimen dosage for perioperative tranexamic acid use. It will benefit patients by reducing allogeneic transfusions and their associated risks and costs, thus adding value to the care delivered.
Interventions
DRUGTranexamic Acid
Tranexamic acid effect on perioperative bleeding in orthopedic surgery
Sponsors
CUF Santarém Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 anos * Total ankle arthroplasty * Total knee arthroplasty * Weight \>50 kilogram
Exclusion criteria
* Allergy and Hypersensitivity to tranexamic acid * Thromboembolic events history * Epilepsy * Acute kidney injury, Glomerular Filtration Rate \< 50 ml/min * Coagulation disorders * Surgical reintervention * Blood transfusion refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Perioperative bleeding | postoperative day 2 | perioperative blood loss measured in mililiters (mL) |
Contacts
Primary ContactAngela Sa, MD
Backup ContactVania Simoes, MD
Outcome results
None listed