Coagulopathy, Hemorrhage, Trauma
Conditions
Keywords
trauma induced coagulopathy, multiple trauma, fibrinogen
Brief summary
The purpose of the study is to find out the incidence of trauma induced coagulopathy in patients with severe trauma who received fibrinogen prior admission to emergency department during prehospital care.
Detailed description
The study will commence following the Approval by The Ethics Research Committee. All patients admitted to emergency department during the study will be enrolled after fulfilling the inclusion criteria and in the absence of any exclusion criteria. Informed consent will be requested. After admission to emergency department the blood samples will be taken and blood tests and viscoelastic tests will be performed. All data and results will be entered in the study form. Statistical analysis will be performed and incidence of trauma induced coagulopathy estimated. In addition, 28-day mortality and the incidence of thromboembolic complications will be monitored.
Interventions
None listed
Sponsors
Brno University Hospital
Masaryk University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* multiple trauma, injury severity score (ISS) ≥16 * administration of fibrinogen in prehospital care * age 18-80 years
Exclusion criteria
* ISS 75 * pregnancy * therapeutic anticoagulation * therapeutic antiaggregation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Trauma induced coagulopathy | day of enrolment | Incidence of trauma induced coagulopathy |
Secondary
| Measure | Time frame |
|---|---|
| 28day mortality | 28 days after enrolment |
| thromboembolic complications | 28 days after enrolment |
Countries
Czechia
Outcome results
None listed