HIV, Infertility
Conditions
Keywords
HIV, Ovarian reserve, Fertility preservation, Anti HIV agents
Brief summary
Recent evidence suggests a decline in fertility of persons living with HIV (PLWH) (delayed pregnancies, sponteanous abortions, especially when patients receive an antiretroviral therapy, early menopause, amenorrhea and anovulatory cycles) with a possible decrease in ovarian reserve. However, indications of fertility preservation by freezing oocytes are nevertheless not clearly identified. The objective of this study is to evaluate the ovarian reserve before and after the implementation of antiretroviral treatment in PLWH for whom the diagnosis of HIV has just been made.
Detailed description
This is a monocentric prospective cohort study with minimal risk and constraints. Ovarian reserve is compared between two groups: 30 PLWH, at time of diagnosis and 6, 12 and 18 months after initiation of an antiretroviral therapy, and 30 HIV negative women attending medically assisted procreation consultation for male infertility, age, BMI and smoking habits matched.
Interventions
DIAGNOSTIC_TESTAMH test
Blood test and pelvic ultrasound are performed at each visit to evaluate ovarian reserve
DIAGNOSTIC_TESTpelvic ultrasound
Blood test and pelvic ultrasound are performed at each visit to evaluate ovarian reserve
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Masking description
No masking
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 37 Years
Healthy volunteers
Yes
Inclusion criteria
* For every participant : * woman aged 18 to 37 * covered by social security * able to give an informed consent Case group only : * diagnosis of HIV infection during the 3 months before inclusion * concomitant initiation of an antiretroviral therapy with integrase inhibitors and nucleoside analogues Control group only : * assisting medically assisted procreation consultation for male infertility * matching case subjects with age, BMI and smoking habits
Exclusion criteria
* For every participant : * current pregnancy * condition or associated treatment that may have an impact on fertility * premature ovarian failure * polycystic ovary syndrome * endometriosis Control group only : \- suspected HIV infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change from inclusion visit AMH level at 18 months | M0 (inclusion visit) and M18 (after 18 months) | blood test to evaluate ovarian reserve thanks to AMH |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| antral follicle count | Month 0 (inclusion visit), Month 6 (after 6 months), Month12 (after one year), Month18 (after 18 months) | pelvic ultrasound to evaluate ovarian reserve thanks to antral follicle count |
| estradiol, lutenizing hormone and follicle-stimulating hormone test | Month 0 (inclusion visit), Month 6 (after 6 months), Month 12 (after one year), Month18 (after 18 months) | blood test |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Outcome results
None listed