Blood Loss, Terlipressin
Conditions
Brief summary
The present study aims to look at the effect of terlipressin infusion on blood loss and blood transfusion needs during Whipple procedure
Interventions
DRUGnormal saline
Patients received 50 ml normal saline at a rate of 100 ml/h followed by a continuous infusion of 50 ml at a rate equal to wt/10 ml per hour and weaned in the postoperative period over 4 hours.
DRUGTerlipressin
Terlipressin is a synthetic vasopressin analogue with relative specificity for the splanchnic circulation(Terlipressin was started at the beginning of surgery as an initial bolus dose of 1 mg over 30 mints(1 mg/50 ml normal saline at a rate of 100 ml/h) followed by a continuous infusion of 2 μg/kg/h(1 mg/50 ml at a rate equal to wt/10 ml per hour) and weaned in the postoperative period over 4 hours.)
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* All patients older than 18 years of age, * ASA classification class I and II, * Patients assigned for Whipple procedure.
Exclusion criteria
* Preoperative renal failure, * Severe liver dysfunction (Child-Turcotte-Pugh grade C), * Hyponatremia (Na+ \<132mmol/l), * Severe valvular heart disease, * Heart failure, * Symptomatic coronary heart disease, * Bradycardic arrhythmia (heart rate \< 60/min), * Peripheral artery occlusive disease (clinical stadium II-IV), * Uncontrolled arterial hypertension (Blood pressure \>160/100mmHg despite intensive treatment), * Pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intraoperative blood loss | intaoperative periods | Amount of intraoperative blood loss in ml |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patients needing blood transfusion | intaoperative periods | Number of patients needing blood transfusion |
| Red blood cell units transfused | intaoperative periods | The number of red blood cell units transfused |
| portal pressure changes | intaoperative periods | portal pressure changes in mmHg |
| ICU stay | postoperative periods | ICU stay in days |
Outcome results
None listed