Comparison of Different Fluence Settings for Yellow Subthreshold Laser Treatment in Diabetic Macular Edema

To Assess the Safety and Efficacy of Two Subthreshold Parameters (5% and 15% Duty Cycle (DC)) Compared to Standard ETDRS (Early Treatment of Diabetic Retinopathy Study) Continuous Wave (CW) Laser

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03571659

Enrollment

Registered

2018-06-27

Start date

2014-12-22

Completion date

2015-08-11

Last updated

2018-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic Retinopathy

Brief summary

To assess the safety and efficacy of two subthreshold parameters (5% and 15% duty cycle (DC)) compared to standard ETDRS (early treatment of diabetic retinopathy study) continuous wave (CW) laser

Detailed description

Test burn up to barely visible burn with micropulse laser, then reduce the power by 70% and perform laser with various DC (5%, 15%, cw) as per the group. Focal to Mas+ confluent burns to areas of diffuse leakage

Interventions

PROCEDURELaser

Study design

Observational model

OTHER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Inclusion criteria

* Eyes with DME (center or non-center involving) with \<350 microns central retinal thickness

Exclusion criteria

* Subfoveal exudates, history of VR surgery, history of macular laser

Design outcomes

Primary

Measure	Time frame	Description
1. Decrease in number of leaking Mas on FFA 2. Decrease in diffuse leakage on FFA	3 months	Comparing the number of leaking microaneuyrms baseline to 6 weeks with 3 types of lasers (two subthreshold parameters (5% and 15% duty cycle (DC)) compared to standard ETDRS continuous wave (CW) laser.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 6, 2026