Investigation of Brain Oxygenation and Blood Flow in Smokers

Investigation of Oxygenation and Blood Flow in the Brain of Smokers and Their Relation to Smoking Abstinence.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03571243

Acronym

OEF

Enrollment

Registered

2018-06-27

Start date

2018-04-30

Completion date

2019-06-30

Last updated

2019-07-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral Oxygenation and Blood Flow in Tobacco Use Disorder

Brief summary

Cerebral oxygenation and blood flow in tobacco use disorder and their relation to smoking abstinence will be measured with MRI ändern in Cerebral oxygenation and blood flow in tobacco use disorder

Detailed description

In this study, cerebral oxygenation and tobacco-related attentional bias in smokers and non-smokers will be measured with magnetic resonance imaging (MRI). In this study, the oxygen extraction fraction (OEF), the cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen (CMRO2) are to be measured in smokers and non-smokers using MRI. On the one hand, the influence of chronic smoking (i.e. smokers versus non-smokers) and on the other hand the effect of acute nicotine administration (in smokers) on these parameters will be examined. Furthermore, the influence of these parameters on fMRI results is to be investigated using the example of a stimulus-reaction task. It can be assumed that the OEF does not change through nicotine administration, but differs in smokers and non-smokers and is associated with the strength of tobacco addiction in smokers. CBF and CMRO2 are expected to be reduced in abstinent smokers, but can be normalized by nicotine administration. In this study, 20 smokers and 10 never-smokers will be investigated. Never-smokers will be examined once with MRI and questionnaires, whereas smokers will be examined twice: before and after a smoking break.

Interventions

OTHERno intervention

observational study

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* age between 18 and 65 * right-handed * normal or correctable eyesight * Sufficient ability to communicate with the investigators, to answer questions in oral and written form * Fully Informed Consent * Written Informed Consent * Group 1 - Smokers: Occasional smoker or tobacco consumption disorder according to DSM 5 * Group 2 - Never-Smokers: Consumption of less than 20 cigarettes in life

Exclusion criteria

* women: pregnancy * Withdrawal of the declaration of consent *

Design outcomes

Primary

Measure	Time frame	Description
MRI data	MRI measurement at one day	oxygenation, blood flow and fMRI data; in smokers pre and post smoking; in never-smokers one session

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026