Hyperoxia Before and After Cardiac Arrest and Myocardial Damage

Hyperoxia Before and After Cardiac Arrest and Myocardial Damage, a Retrospective Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03571074

Enrollment

163

Registered

2018-06-27

Start date

2018-05-30

Completion date

2018-09-30

Last updated

2018-10-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest

Brief summary

Several studies show how patients with hyperoxia after cardiac arrest has increased mortality, but the association of hyperoxia before cardiac arrest and myocardial damage has never been investigated. Neither has the association between hyperoxia after cardiac arrest and myocardial injury. Our research hypothesis is that hyperoxia before cardiac arrest aggravates myocardial damage, secondly we wish to analyze the association between hyperoxia after cardiac arrest and myocardial injury. The exposure variables is oxygenation within 48 hours before and 48 hours after cardiac arrest, our primary outcome is myocardial damage and will be measured as peak troponin within 30 days after cardiac arrest.

Interventions

OTHEROxygenation

Oxygenation measured as oxygen supply and saturation before cardiac arrest, and oxygenation measured as PaO2 after cardiac arrest.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 18 years or older * With a record of ICD-10 diagnosis of cardiac arrest in 2014, admitted to a hospital in the Capital Region of Denmark. * First recorded cardiac arrest in 2014 * Admitted to ICU * Serum troponin measured within 7 days after cardiac arrest

Exclusion criteria

* Out of hospital cardiac arrest, OHCA * In of hospital cardiac arrest, IHCA, but with no registered saturation before cardiac arrest.

Design outcomes

Primary

Measure	Time frame	Description
Peak troponin within 30 days after cardiac arrest	30 days	Troponin measurements on patients after cardiac arrest.

Secondary

Measure	Time frame
30-day and 1-year mortality	Up to 1 year.
Troponin area under the curve within 3 days after cardiac arrest	3 days
Length of ICU stay after cardiac arrest	through study completion,on average of 4-8 weeks.
Length of hospital stay after cardiac arrest	through study completion,on average of 4-8 weeks.

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026