Lung Cancer
Conditions
Brief summary
This study was a prospective, randomized, controlled, and double-blind trial. Major assessments were made during the operation and 48 h postoperatively.
Detailed description
The prime outcomes were the time in minutes from leave the postoperative care unit to the first patient-controlled intravenous analgesia press.The secondary outcomes were to compare the following: (1)blood concentrations of ropivacaine was measured at 0.5 h, 1 h, 2 h, 3 h, and 24 h after paravertebral nerve block; and (2) the patient's intraoperative opioid use, phenylephrine use, fluid intake, urine output, dry mouth score, and 24 h and 48 h visual analogue scale.
Interventions
DRUGDexmedetomidine Group
combination of ropivacaine and dexmedetomidine 100 ug every time
combination of ropivacaine and dexamethasone 10mg every time
DRUGcontrol group
block with only ropivacaine
Sponsors
China Medical University, China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Intervention model description
thoracic paravertebral blocks using a combination of ropivacaine and dexmedetomidine or dexamethasone
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* (1) age 18 to 65 years, * (2) scheduled to undergo video-assisted thoracic surgery, * (3) American Society of Anesthesiologists risk classification I-II.
Exclusion criteria
* (1) patient refusal; * (2) known hypersensitivity to the study medication (ropivacaine); * (3) long-term use of opioids; * (4) liver or renal insufficiency; * (5) a history of psychiatric or neurological disease; * (6) deafness; * (7) regular use of acetaminophen, nonsteroidal anti-inflammatory drugs, corticosteroids, or antiemetics; and * (8) a preoperative Pittsburgh Sleep Quality Index (PSQI) global score higher than 6.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of thoracic paravertebral block analgesia duration | Change from Baseline to 2 days after surgery | The prime outcomes were the time in minutes from leave the postoperative care unit to the first patient-controlled intravenous analgesia press |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| blood concentrations of ropivacaine | Change from Baseline to 2 days after surgery | (The secondary outcomes were to compare the following: (1)blood concentrations of ropivacaine was measured at 0.5 h, 1 h, 2 h, 3 h, and 24 h after paravertebral nerve block; and (2) the patient's intraoperative opioid use, phenylephrine use, fluid intake, urine output, dry mouth score, and 24 h and 48 h visual analogue scale. |
Countries
China
Outcome results
None listed