Optic Neuritis
Conditions
Brief summary
Can diffusion tensor imaging (DTI) of the optic ways contributes to predict the 6 months prognosis of Optic Neuritis (ON)?
Interventions
DEVICEMRI
MRI in diffusion tensor (DTI : Diffusion Tensor Imaging)
Sponsors
Rennes University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
Interventional pilot study with minimal risks and constraints, descriptive, prospective, monocentric
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Age from 18 to 55 years old * Clinically suspected optic neuritis defined as a sudden decrease of the visual acuity and/or a damage to the field of vision and/or a defect of the colour vision and/or retro-orbital pain with a relative afferent pupillary defect (except if the optic neuropathy is bilateral or symmetrical), in the absence of a severe retinal macular pathology, and in the absence of a toxic or iatrogenic intake (ethambutol, vfend) * Clinical optic neuritis duration \< 15 days * First episode of an inflammatory ON * No corticosteroids in the month before * Indication to a corticosteroid therapy at high dose to cure the felt symptomatology * Retinal nerve fibre layer (RNFL) thickness upper 75 µm at initial stage * Isolated ON, multiple sclerosis or NMO (Neuro Myelitis Optica) - SD (Spectrum Disorder) context * Having signed informed consent for participating in the study
Exclusion criteria
* Contra-indication to MRI * Cardiac pacemaker or defibrillator implant * Neurosurgical clips * Cochlear implants * Intra-orbital or encephalic foreign bodies * Stents implanted since less than 4 weeks and osteosynthesis equipment implanted since less than 6 weeks * Claustrophobia * Persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty * Eye examination suggests a pre-existing eye abnormality that could affect the visual function (amblyopia, strong myopia…) * Pregnant or breastfeeding women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Study of DTI markers in the assessment of the visual prognosis at 6 months of an inflammatory NO based on RNFL thickness (< ou > 75 µm) | Month 6 | MRI |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Study of DTI markers in the assessment of the visual prognosis at 6 months of an inflammatory NO based on visual acuity and/or sensible damage to the field of vision | Month 6 | MRI |
| Comparison of the structural anomalies detected in DTI to the standard morphological MRI (Coronal T2 Fat-Sat MRI and T1 Gadolinium) for ON | Month 6 | MRI |
Countries
France
Outcome results
None listed