Anesthesia
Conditions
Brief summary
The aim of this study is to compare the peripheral perfusion index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent inhalation anesthesia.
Detailed description
Ether derivative anesthetics, including sevoflurane and desflurane, have direct activity on vascular tissue and both are vasodilators. However, there has been no direct comparison of vasodilative effect between sevoflurane and desflurane in vivo in humans. Peripheral perfusion index derived from photoplethysmographic waveform reflects peripheral vasomotor tone. Therefore, the purpose of this study is to compare the peripheral perfusion index values produced by sevoflurane and desflurane at equipotent concentration in patients undergoing single-agent inhalation anesthesia.
Interventions
DRUGSevoflurane
End-tidal concentration of sevoflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.
DRUGDesflurane
End-tidal concentration of desflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.
Sponsors
Kangbuk Samsung Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients aged between 19 and 65 yr * patients with American Society of Anesthesiologists physical status classification I or II * patients scheduled for elective arthroscopic knee surgery under general anesthesia * patients obtaining written informed consent
Exclusion criteria
* patients with a history of any disease associated with the autonomic nervous system * patients receiving any medication affecting the sympathetic or parasympathetic nervous systems * patients with cardiac arrhythmia, diabetes mellitus, and alcohol or drug abuse * pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| peripheral perfusion index | After a 30-min waiting period from the induction of anesthesia | peripheral perfusion index value at a steady-state anesthesia of age-corrected 1.0 MAC |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| mean arterial pressure | After a 30-min waiting period from the induction of anesthesia | mean arterial pressure at a steady-state anesthesia of age-corrected 1.0 MAC |
| heart rate | After a 30-min waiting period from the induction of anesthesia | heart rate at a steady-state anesthesia of age-corrected 1.0 MAC |
Countries
South Korea
Outcome results
None listed