Muscle Weakness, Weaning Failure
Conditions
Keywords
abdominal muscles, spontaneous breathing trial, critically ill patients
Brief summary
The purpose of the study is to determine to what extent the abdominal muscles contribute to airway pressure, in order to investigate the correlation between muscles weakness and extubation outcome in mechanically ventilated patients. In addition the reliability of the sonographic measurements will be assessed.
Detailed description
The purpose of the study is to determine to what extent the abdominal muscles contribute to airway pressure, in order to investigate the correlation between muscles weakness and extubation outcome in mechanically ventilated patients. In addition the reliability of the sonographic measurements will be assessed.
Interventions
DIAGNOSTIC_TESTAbdominal muscles ultrasound
Abdominal muscles ultrasound during a spontaneous breathing trial using the M-mode to calculate the thickening fraction of the anterior and lateral abdominal muscles under multiple circumstances (tasks performed by the patients)
Sponsors
University of Toronto
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* greater than 18 years old * Patients requiring invasive mechanical ventilation including patients with endotracheal tube and tracheotomies
Exclusion criteria
* Patients with a previously diagnosed neuromuscular disorder (acute or chronic) * Behavioural agitation * Patients who are not awake and cooperative * Previously enrolled in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between thickening fraction and SBT outcome | Measurements will be performed before SBT | Correlation between thickening fraction of each muscles evaluated by ultrasound before the SBT and the SBT outcome. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between the pressures generated by respiratory muscles and SBT outcome | Measurements will be performed before SBT | Correlation between the pressures generated by respiratory muscles during the ultrasound measurements (Twice Transdiaphragmatic pressure, TwPdi; maximal inspiratory pressure, MIP) and SBT outcome |
| Inter-rater agreement | Measurements will be performed before SBT | Concordance of measurements of abdominal muscle thickness and thickening fraction in mechanically ventilated patients performed by two different observers will be evaluated. |
Countries
Canada, Italy
Outcome results
None listed