Anesthesia, General, Infant
Conditions
Keywords
Pediatric Anesthesia, Near-Infrared Spectroscopy, End-Tidal CO2, Cerebral Blood Flow
Brief summary
The study aims at assessing cerebral blood flow variations following expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia.
Detailed description
The study aims at assessing cerebral blood flow (measured with Near-Infrared Reflectance Spectroscopy - NIRS - and transcranial Doppler - DTC) variations following end-tidal expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia performed according to standards of care.
Interventions
PROCEDUREEtCO2 modification
Controlled modification of EtCO2 through modification of ventilation parameters under general anesthesia without spontaneous breathing
Sponsors
St. Justine's Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Masking description
Patient is under general anesthesia
Intervention model description
Cerebral blood flow is measured in each patient at 3 different, controlled levels of end-tidal CO2
Eligibility
Sex/Gender
ALL
Age
No minimum to 6 Months
Healthy volunteers
Yes
Inclusion criteria
* Age \< or = 6 months * ASA class \< or = 3 * General anesthesia required for surgery
Exclusion criteria
* No parental consent * Emergency surgery * Preexisting neurological condition * Hemodynamic instability * Preexisting hypoxemia and/or hypercapnia * Laparoscopy or thoracoscopy, if expected EtCO2 level achieving would require unsafe ventilation parameters
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| NIRS variation | 5 to 10 minutes | Near-Infrared Spectroscopy value variation after EtCO2 modification |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| DTC variation | 5 to 10 minutes | Transcranial Doppler values variation after EtCO2 modification |
Countries
Canada
Outcome results
None listed