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Epidemiology of Chronic Hepatitis C and Disease Modelling

Epidemiology of Chronic Hepatitis C and Modelling for Disease Burden Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03566563
Acronym
EPIC
Enrollment
520
Registered
2018-06-25
Start date
2017-02-21
Completion date
2020-05-29
Last updated
2020-10-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatitis C

Keywords

Community Screening, Halfway house, People who inject drugs, Substance users, Released prisoners

Brief summary

Hepatitis C (HCV) is a major health problem amongst people who inject drugs (PWID) and have limited contact with health care services. Halfway houses (HH) serve to reintegrate former drug users into society. Strategies to eliminate HCV must focus on screening for HCV amongst HH. Linkage to care for PWID population is an issue globally. The aim is to determine the sero-prevalence, demographics, disease distribution and factors associated with the risk of HCV transmission amongst former drug users at Halfway Houses. The secondary aim would be to determine the best models of care that can be used to link these individuals to existing healthcare services in a pragmatic, randomised fashion Halfway Houses are invited to participate in a program of HCV education, point-of-care screening using Oraquick test and staging with Fibroscan® by a small mobile team of healthcare workers. A detailed survey regarding illicit drug injecting practices is performed. Those who are tested positive are referred to medical care. It is anticipated that the prevalence of Hepatitis C within the drug injecting population along with the stages of liver disease such that models for disease burden can be determined.

Detailed description

This is a pragmatic observational study of point of care HCV screening in the halfway house resident /PWID population. In the secondary aim the HCV positive subjects are randomised to traditional referral pathway (HCV positive cases attend primary care facilities to get referral to specialist clinic in hospital) and 'direct' open access where the HCV positive cases has direct open access to specialist clinic as above (by passing primary care physicians). We observe the no. of subjects being linkage to specialist care, and HCV treatment

Interventions

OTHERScreening

Patients tested positive for Hepatitis C will be referred to Hospital through the conventional health care services and by an alternative direct access method to determine if this improves linkage to care

Sponsors

National University Hospital, Singapore
CollaboratorOTHER
Changi General Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
21 Years to No maximum

Inclusion criteria

* Former Drug Users residing in Halfway Houses

Exclusion criteria

* Age below 21 years * Residents of Halfway Houses who have never used drugs

Design outcomes

Primary

MeasureTime frameDescription
HCV Sero-prevalence at Halfway Houses24 monthsThe number of HCV Sero positive cases at Halfway Houses will be measured

Secondary

MeasureTime frameDescription
Linkage to Care24 monthsThe number of patients linked to care will be compared between the intervention arm and conventional arm

Other

MeasureTime frameDescription
Disease burden estimation24 monthsThe number of HCV positive cases in Singapore will be estimated

Countries

Singapore

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026