Skip to content

The Effects of Dietary Salt on Post-exercise Hypotension

The Effects of Dietary Salt on Post-exercise Hypotension

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03565653
Enrollment
20
Registered
2018-06-21
Start date
2018-05-01
Completion date
2019-07-01
Last updated
2019-10-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Pressure, Post-Exercise Hypotension

Brief summary

The new American Heart Association (AHA) blood pressure guidelines are expected to raise the prevalence of high blood pressure to \ 46% in the United States. One recommendation for lowering blood pressure is aerobic exercise, which produces a period of lowered blood pressure (post-exercise hypotension; PEH) that lasts up to 24 hours. It is believed that PEH may be responsible for the observations of lowered blood pressure following initiation of exercise. However, most Americans eat too much salt, which expands plasma volume and may prevent PEH, rending aerobic exercise ineffective in improving blood pressure status.

Detailed description

Recently released blood pressure guidelines from the American Heart Association and American College of Cardiology are expected to raise the prevalence of hypertension in America from \ 33% to \ 46%. A single bout of aerobic exercise produces a prolonged period (up to 24 hours) of lowered blood pressure (post-exercise hypotension; PEH). Repeated bouts of aerobic exercise results in maintenance of lowered blood pressure, leading to recommendations of aerobic exercise for improvement of blood pressure status. However, more than 90% of Americans consume more sodium in their diets than is recommended. This is alarming, as excess dietary sodium intake expands plasma fluid volume, which may in turn attenuate the reduction in BP following exercise. Therefore, the objective of this project is to determine the effects of high dietary sodium intake on PEH. The investigators hypothesize that, compared to a recommended sodium diet, a high salt diet will attenuate post-exercise hypotension.

Interventions

\ 4,000 mg Na+/day

OTHERPlacebo

dextrose

Sponsors

University of Delaware
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* Recreationally active

Exclusion criteria

* high blood pressure (\>140/90 mmHg) * history of cardiovascular disease * history of cancer * history of diabetes * history of kidney disease * obesity (BMI \> 30 kg/m2) * smoking or tobacco use * current pregnancy * nursing mothers * communication barriers

Design outcomes

Primary

MeasureTime frameDescription
Post-exercise hypotension24 hours following exerciseChange in mean arterial pressure from pre- to post-exercise

Secondary

MeasureTime frameDescription
Blood pressure reactivity10th day of high salt dietChange in mean, systolic, and diastolic blood pressure from baseline to exercise

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026