Atrial Fibrillation
Conditions
Brief summary
Identify the parameters of the predictive isochronous map for the clinical outcome of radiofrequency ablation in terms of absence of documented atrial fibrillation recurrence at 18 months.
Interventions
PROCEDUREExternal electric cardioversion
Three attempts (200-250 joules)
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* The patient must have given their free and informed consent and signed the consent form * The patient must be a member or beneficiary of a health insurance plan * The patient is at least 18 years old * The patient is available for 18 month follow-up * The patient has paroxysmal or persistent atrial fibrillation
Exclusion criteria
* The subject is participating in a category 1 interventional study, or is in a period of exclusion determined by a previous study * The subject refuses to sign the consent * It is impossible to give the subject informed information * The patient is under safeguard of justice or state guardianship * The patient is pregnant or breastfeeding Early Study Exit Criteria: Patient does not have paroxysmal or persistent AF at the time of inclusion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Atrial fibrillation relapse in non-reducible or non-inducible patients | Month 18 | Atrial fibrillation detected by routine or event-associated Holter examination |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Arrhythmia occurrence in non-reducible or non-inducible patients | Month 12 | Arrhythmia, including atrial tachycardia detected by routine or event-associated Holter examination |
| Identification of zones of low voltage on voltage maps in non-inducible patients | Day 0 | Yes/No |
| Identification of zones of anisochronic zones on voltage maps in non-inducible patients | Day 0 | Yes/No |
| Maximum variation of conduction speed in the same anatomic region in non-inducible patients | Day 0 | % |
| Decreasing velocities in the same anatomic region in non-inducible patients | Day 0 | % |
| Wave front rotation in the same anatomic region in non-inducible patients | Day 0 | degrees |
| Atrial fibrillation relapse in non-reducible or non-inducible patients | Month 12 | Atrial fibrillation detected by routine or event-associated Holter examination |
| Total procedure time in non-inducible patients | Day 0 | Minutes |
| Comparison of lesion volume in non-inducible patients | Day 0 | Force-time integral, lesion size index or stroke volume index |
| Number and size of treated zones by guided versus conventional ablation in non-inducible patients | Day 0 | cm2 |
| List locations most frequently treated | Day 0 | Number of each |
| Survival without relapse of patients treated using the Carto- vs Rhythmia-guided ablation approaches in non-reducible or non-inducible patients | Month 18 | Atrial fibrillation detected by routine or event-associated Holter examination |
| Total time of radiofrequency in non-inducible patients | Day 0 | Minutes |
Countries
France
Outcome results
None listed