Oxidative Stress
Conditions
Keywords
Minimal Flow Anesthesia, Thiol/disulfide balance, Tissue oxygen saturation, hypotensive anesthesia
Brief summary
The effects of Minimal Flow Anesthesia (0.4 l / min) and High Flow Anaesthesia (2 l / min) on tissue oxygen saturation (St02) and thiol / disulfide balance in hypotensive anesthesia operations will be investigated.
Detailed description
The oxidative stress at the cellular level and the possible effects of general anesthesia techniques on the antioxidant system make the method of anesthesia more important. The effects of Minimal Flow Anesthesia (0.4 l / min) and High Flow Anaesthesia (2 l / min) on tissue oxygen saturation (St02) and thiol / disulfide balance in hypotensive anesthesia operations will be investigated. Minimal flow anesthesia is widely used because of its advantages such as cost reduction, prevention of environmental pollution, minimization of heat and humidity loss. Hypotensive anesthesia is preferred in some specialized surgical procedures in order to reduce bleeding and improve the surgical field of view. The use of hypotensive anesthesia and inhalation agents may cause hypoperfusion at the tissue level and cause hypoxia-induced oxidative stress and initiate cell damage. Determining the ideal anesthesia technique in terms of oxidative stress and tissue perfusion will reduce intra- and postoperative risks by protecting patients from the harmful effects of anesthesia.
Interventions
Minimal Flow Anesthesia with 0,4 L min-1
OTHERHigh Flow Anesthesia
High Flow Anesthesia with 2 L min-1
Sponsors
Recep Tayyip Erdogan University Training and Research Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* ASA (American Society of Anesthesiologists) I tympanoplasty operations with hypotensive anesthesia, * ASA (American Society of Anesthesiologists) II tympanoplasty operations with hypotensive anesthesia,
Exclusion criteria
* operations in less than one hour * uncontrolled hypertension * DM (Diabetes Mellitus) * cerebrovascular disease * coagulopathy * morbid obesity ((BMI ≥ 35) * renal disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Thiol Disulfide Balance | For two groups; First blood sample will be taken 30 min before the start of surgery, second blood sample will be taken at the 60th min of the surgery | Change of Oxidative Stress Marker |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| StO2 | For two groups; simultaneously, 30 min before the start of surgery, 60th min of the surgery | Change of Peripheral Tissue Oxygen Saturation |
Countries
Turkey (Türkiye)
Contacts
Primary ContactŞule Batçık, Asst. Prof.
Backup ContactLeyla Kazancıoğlu, Asst. Prof.
Outcome results
None listed