Delirium, Sepsis, Septic Encephalopathy
Conditions
Keywords
Sepsis, Encephalopathy, Delirium, ICU, EEG, MRI, Cognitive tests
Brief summary
The research program explores how delirium influenced brain function in patients surviving delirium and septic encephalopathy from a non neurological specialized ICU cohort from 2013 to 2015 in Rigshospitalet (Glostrup).
Detailed description
The overall aim is to understand the pathophysiological mechanism in delirium and septic encephalopathy and its consequences. For this purpose we will: 1. Provide extensive cognitive testing. These results provide the basis for categorization of patients surviving septic encephalopathy and delirious patients. 2. First, the investigators will examine if the differences in cognitive function is reflected in the ability of the brain to generate high-frequency electrical oscillations that accompany and underlie perception, attention, cognition, memory formation and retrieval. It will be performed by carrying out continuous EEG (cEEG) and by examination of steady-state evoked cognitive EEG responses. 3. Second, the investigations will examine MRI, structural and diffusion tensor imaging sequences. Hippocampal, thalamic, amygdala, lentiform nucleus and cingulate cortex volumes will be determined bilaterally and will be compared between individuals with healthy brain aging and patients that survived delirium. 4. Third, the investigators will assess plasma markers of free radical production.
Interventions
OTHERDelirium and with septic encephalopathy.
Delirium or septic encephalopathy survivors will be analized in the same way: Cognitive tests, EEG and MRI.
Sponsors
University of Copenhagen
Rigshospitalet, Denmark
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
for the ICU cohort: * Age \>18 years; * Length of stay \>24 hours in the ICU.
Exclusion criteria
for the ICU cohort: * Expected death \<24 hours; * Psychiatric illness; pre-existing delirium; severe dementia; cerebrovascular event \<six months; major surgery \<two months; * Non-Danish or English speaking.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EEG frequencies | Through study completion, an average of 1 year | Automatically measurments of frequencies band |
| MRI | Through study completion, an average of 1 year | Structural and diffusion tensor imaging sequences |
| Cognitive test: Verbal-Paired Associates | Through study completion, an average of 1 year | Assessing explicit episodic memory performance |
| Cognitive test: Mini-Mental State Examination (MMSE) | Through study completion, an average of 1 year | neurocognitive function |
| Cognitive test: Trail-Making Test and the Symbol-Digit Modalities Test (SDMT), | Through study completion, an average of 1 year | Speed of processing and executive functioning |
Countries
Denmark
Outcome results
None listed