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Effect of Anaesthesia on ER Stress in Cancer Patients

Evaluation the Effects of Anaesthetic Agents on Endoplasmic Reticulum Stress During Cancer Surgery

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03561831
Enrollment
53
Registered
2018-06-19
Start date
2018-06-05
Completion date
2019-05-29
Last updated
2021-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endoplasmic Reticulum Stress

Brief summary

Investigate the change in endoplasmic reticulum stress after cancer surgery according to different anaesthetics including propofol and sevoflurane.

Detailed description

We hypothesize propofol and sevoflurane based anesthesia would show different pattern of endoplasmic reticulum stress after cancer surgery in patients with cancer

Interventions

DRUGPropofol

propofol based anesthesia

DRUGSevoflurane

sevoflurane based anesthesia

Sponsors

Konkuk University Medical Center
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
FEMALE
Age
20 Years to No maximum
Healthy volunteers
No

Inclusion criteria

\- patients with cancer

Exclusion criteria

* age under 19 years old * allergy history to propofol or sevoflurane * history of previous cancer

Design outcomes

Primary

MeasureTime frameDescription
Change in endoplasmic reticulum stressbaseline, postoperative 1 hours and 24 hoursChange in endoplasmic reticulum stress

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026