Anesthetic Neurotoxicity, Development Delay, Seizures
Conditions
Keywords
Pediatric, MRI Indications, Anesthesia, Anesthetic Neurotoxicity, MRI Diagnostic Yield
Brief summary
The investigators aim to identify the frequency with which an elective brain MRI yields and etiologic diagnosis to explain its indication. The protocol includes children undergoing elective brain MRI with anesthesia prior to their third birthday.
Detailed description
On December 14, 2016 the FDA issued a warning regarding elective anesthetics in children under three years of age. While a single, short exposure to general anesthesia may not have negative effects on behavior or learning, repeated or prolonged anesthetics may affect brain development. To that end, minimizing exposure to elective general anesthetics if procedures are not clearly indicated in young children appeals to reason.
Interventions
DIAGNOSTIC_TESTChange in plan of care based on MRI results
Study subjects have received the intervention if the results of their MRI either 1. provide an etiology for said MRI's indication or 2. the patient received a change in plan of care based on MRI results.
Sponsors
Baylor College of Medicine
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 1095 Days
Healthy volunteers
No
Inclusion criteria
* Male or female aged 0-36 months who received anesthesia (volatile gas anesthesia) or IV sedation (propofol, dexmedetomidine, barbiturates, benzodiazepines, or other agents) for brain MRI
Exclusion criteria
* MRI without sedation, brain MRI plus additional MRI imaging, i.e. spine, heart, etc., sedated MRI by a member of other department besides Anesthesiology.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Etiologic diagnosis obtained from MRI brain | 1 year | Determine the incidence of brain MRI abnormality that led to etiological explanation of developmental delay, autism or seizure. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quantify anesthetic exposure | 1 year | To determine the doses of all anesthetic and sedative agents administered and the duration of anesthesia |
| Incidence of repeat MRI | 1 year | To determine the incidence of repeat MRI scan in the study population. anesthesia. To determine the incidence of repeat MRI scan in the study population. |
Countries
United States
Outcome results
None listed