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Embryotransfer Operator and Pregnancy Rate

Does the Operator Performing the Embryo Transfer Significantly Influence the Cycle Outcome: A Retrospective Evaluation of Humanitas Fertility Center's Experience

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03561129
Acronym
Operator
Enrollment
200000
Registered
2018-06-19
Start date
1997-01-01
Completion date
2017-12-31
Last updated
2018-06-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sterility

Brief summary

Several studies had analyzed the correlation between embryo transfer operator experience and implantation, clinical pregnancy, abortion and delivery rate. The aim of the present study is determining if the probabilities of embryo implantation and pregnancy are associated to the operator performing the embryo transfer. This study allows following more than 30 different operators in a global period of 20 years with almost 20,000 procedures.

Detailed description

Several studies had analyzed the correlation between embryo transfer operator experience and implantation, clinical pregnancy, abortion and delivery rate. Until now, the evidences are mixed and inconclusive. The aim of the present study is determining if the probabilities of embryo implantation and pregnancy are associated to the operator performing the embryo transfer. The database includes all the fresh embryo transfers, performed between January 1997 and December 2016 at Humanitas Fertility Center after IVF-ICSI cycles. Only embryo transfers performed by the surgeon on duty for that day (Gynecologist of the Day) will be included. Secondary end point is to evaluate if it is possible to draw a learning curve for transfer in terms of pregnancies for the different surgeons. The strength of this study relies on the completeness of the preoperative factors and follow up and on the vastest dataset in literature that can permit to correct for multiple confounders and analyze a wide group of outcomes.

Interventions

OTHEREmbryo transfer

all the fresh embryo transfers, performed between January 1997 and December 2016 at Humanitas Fertility Center after IVF-ICSI cycles, divided per operator

Sponsors

Istituto Clinico Humanitas
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 48 Years
Healthy volunteers
No

Inclusion criteria

* fresh embryos' transfers * embryo transfers performed only by the surgeon on duty for that day (Gynecologist of the Day)

Exclusion criteria

* cryo thawed embryos' transfers

Design outcomes

Primary

MeasureTime frameDescription
Pregnancy rate per operator20 yearsnumber of viable intrauterine embryos/ total number of embryos transferred per operator

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 28, 2026