Poor Responders in IVF
Conditions
Brief summary
Poor ovarian response population of ART are considered the biggest challenge for providers. Hitherto, no one protocol has been proven to be effect in this subgroup of IVF patients. Metoclopramide belongs to the antiemetic group, used for motion sickness and during early gestation for hyperemesis gravidarum. The mechanism of action is antagonisim to dopamine receptors. We hypothesize than by blocking dopamine receptors and decreasing the dopaminergic tone there is a possibility to increase the sensitivity of ovarian response to gonadotropins during controlled ovarian stimulation and result in increased oocyte retrival.
Interventions
DRUGMetoclopramide
Metoclopramide 10 mg BID
DRUGPlacebo Oral Tablet
Placebo 10 mg BID
Sponsors
Barzilai Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 54 Years
Healthy volunteers
Yes
Inclusion criteria
* Poor response according to Bologna criteria
Exclusion criteria
* Allergy to metoclopramide * Prolactinemia * Women treated with dopamine agonists
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of oocytes | Approximately 5 weeks from first dose of study drug | Number of oocytes |
Countries
Israel
Contacts
Primary ContactLeon Grin, MD
Outcome results
None listed