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Objective Verification of Physiologic Changes During Accommodation Under Binocular, Monocular, and Pinhole Conditions

Objective Verification of Physiologic Changes During Accommodation Under Binocular, Monocular, and Pinhole Conditions

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03557346
Enrollment
64
Registered
2018-06-15
Start date
2017-01-02
Completion date
2017-03-31
Last updated
2018-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Accommodation

Brief summary

The investigators believe that this simple, clear, and objective study may be a great help in understanding the accommodative response during various accommodative stimulation conditions.

Detailed description

The purpose in this study was to investigate physiological changes in accommodative power, pupil diameter, astigmatic value, and axis when visual stimuli were applied under binocular, monocular (dominant eye, non-dominant eye, ipsilateral, and contralateral), and pinhole conditions using the WAM-5500 binocular autorefractor/keratometer (Grand Seiko Co. Ltd., Hiroshima, Japan).

Interventions

DEVICEthe WAM-5500 binocular autorefractor/keratometer (Grand Seiko Co. Ltd., Hiroshima, Japan)

: Subjects underwent a basic ophthalmic examination and the accommodative response to refractive stimuli was measured. Refractive stimuli were given at 0.25 diopters (D) (4 m distance), 2D (50 cm), 3D (33 cm), and 4D (25 cm) and stimulation was applied with the eyes in binocular, monocular (dominant eye, non-dominant eye, ipsilateral, and contralateral), and pinhole conditions. In addition, changes in the astigmatic value and direction of the astigmatism axis under binocular stimulus were evaluated.

Sponsors

Chung-Ang University Hosptial, Chung-Ang University College of Medicine
Lead SponsorOTHER

Study design

Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

1. age between 20 and 40 years 2. spherical equivalent (SE) within ± 4.0 diopters (D) 3. correctable distant and near visual acuity by glasses to 20/20 4. normal ocular alignment.

Exclusion criteria

1. disturbance of accommodation (e.g., Adie's pupil, Parkinson's disease, accommodative esotropia, accommodative spasm, presbyopia) 2. disorders that can affect accommodation (e.g., history of ocular trauma, previous ocular surgery) 3. disorders that might limit testing accuracy (e.g., corneal pathological features, cataract, glaucoma, vitreous opacity, and retinal abnormalities).

Design outcomes

Primary

MeasureTime frameDescription
Accommodative powerSubjects performed this examination while being under binocular, monocular, and pinhole conditions with one week apart in random order after baseline studyAccommodative powers in diopters were measured using WAM-5500 binocular autorefractor/keratometer
Pupil diameterSubjects performed this examination while being under binocular, monocular, and pinhole conditions with one week apart in random order after baseline studyPupil diameters in millimeters were measured using WAM-5500 binocular autorefractor/keratometer
Astigmatic value and axis changeSubjects performed this examination while being under binocular, monocular, and pinhole conditions with one week apart in random order after baseline studyAstigamtic value in diopters and axis change in degrees were measured using WAM-5500 binocular autorefractor/keratometer The spherical equivalent (sphere + 1/2 cylinder) was used to assess the response to refractive stimuli. The principal meridian of the cylinder for 0.25D refractive stimulus was set to the baseline axis. For 2D, 3D, and 4D refractive stimuli, vertical movement was determined when the baseline meridian moved to the 90' axis, and it was considered horizontal movement when it moved to the 0' or 180' axis.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 22, 2026