Environmental Factor and Onset of Spontaneous Pneumothorax

Impact of Meteorological Conditions on the Onset of First Episod of Spontaneous Pneumothorax : a French Multicenter Case-crosserover Study About 945 Subjects in 14 Centers

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03557320

Acronym

EXPPO

Enrollment

3090

Registered

2018-06-15

Start date

2013-05-31

Completion date

2014-06-30

Last updated

2020-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spontaneous Pneumothorax

Keywords

environment, pressure, temperature, case-crossover

Brief summary

The study aims to evaluate the association between spontaneous pneumothorax onset and weather parameters.

Detailed description

The aim of this study is to analyse the relation between onset of the PSP and exposure to environmental factors such as atmospheric pressure. A case-crossover epidemiological study will be conducted in 14 French hospitals. SP recorded from 2009 to 2013 will be exhaustively included. Demographic and clinical characteristics will be collected. For each incident case of SP, the period of occurrence of the event (case period) will be compared to several other periods temporally distant from the case period (control periods prior to and after the event). Exposure will be assessed using meteorological stations localized in the vicinity of each patient's home. A potential threshold effect and/or time lag effect between exposure and admission for SP will be explored. The results of this study will help to identify the meteorological factors associated with the occurrence of SP, and to deepen our knowledge of the pathophysiological mechanisms of SP especially the influence of meteorological factors on bleb rupture.

Interventions

None listed

Study design

Observational model

CASE_CROSSOVER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* age over 18 years * first episode of primary spontaneous pneumothorax

Exclusion criteria

* Patients with traumatic * Patients with secondary pneumothorax * Patients with recurrent pneumothorax and patients with short-term readmissions (recurrence was defined as a new ED admission for the same diagnosis more than 14 days after the first admission).

Design outcomes

Primary

Measure	Time frame
Estimate odds ratio for the association between meteorological data and onset of PSP.	28 days

Countries

France

Outcome results