Anesthesia, Obestetric
Conditions
Brief summary
Beta trace protein assay is an indicator of post-spinal CSF leak that predicts the degree of post-spinal headache.
Detailed description
Beta trace protein is specific for CSF only and it is a quantitative analytic test.
Interventions
DEVICEspinal needle
It is a spinal needle with 'QUINCKE' Bevel. It is inserted in the lumbar region at the inter-space L4-L5, L4-L3 ,or L3-L2 lumber spaces, while the patient is put in the sitting position then CSF sample is taken then 2.5 ml of a local anesthetic(0.5 ml of 25 ug fentanyl and 2 ml of 8 mg heavy bupivacaine) is given intrathecal then the needle is withdrawn.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-45 years old * free medical history. * free obstetric history.
Exclusion criteria
* high risk pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CSF sample: serum sample | One year | After insertion of an intravenous line 4 ml serum will be collected, then 0.5 ml CSF sample will be collected after insertion of the dura by the selected spinal needle before injecting the anesthetic drugs used for spinal anesthesia. Beta trace protein assay will be measured through ELISA technique in both CSF and serum samples and the ratio will be calculated and measured. This ratio will be measured for the three arms aiming at the comparison between the three devices regarding the CSF : Serum ratio. |
Countries
Egypt
Outcome results
None listed